Abstract
Two infants severely ill at birth as a result of congenital cytomegalovirus infection were born in Halifax, Nova Scotia, in April and July 1968. Both died within seven weeks. Clinical, pathological and virological studies including serology and electron microscopy were made both before and after death. Cytomegalovirus was isolated in tissue culture from urine specimens from both infants during life and from organ tissues, blood and ascitic fluid after death. Large inclusion-bearing cells mixed with the erythrocytes and leukocytes were seen within the lumina of pulmonary blood vessels. A brief general discussion is presented of the various clinical manifestations of congenital cytomegalovirus infection and of the different serum antibody patterns found in these two pairs of mothers and infants.
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- Dudgeon J. A. Breakdown in maternal protection: infections. Proc R Soc Med. 1968 Nov;61(11 Pt 2):1236–1243. doi: 10.1177/003591576806111P209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Embil J. A., Jr, Ozere R. L., Van Rooyen C. E. Cytomegalic inclusion disease: a case report with isolation of virus. Can Med Assoc J. 1965 Dec 11;93(24):1268–1273. [PMC free article] [PubMed] [Google Scholar]
- Foster K. M., Jack I. Isolation of cytomegalovirus from the blood leucocytes of a patient with post-transfusion mononucleosis. Australas Ann Med. 1968 May;17(2):135–140. doi: 10.1111/imj.1968.17.2.135. [DOI] [PubMed] [Google Scholar]
- Hanshaw J. B., Steinfeld H. J., White C. J. Fluorescent-antibody test for cytomegalovirus macroglobulin. N Engl J Med. 1968 Sep 12;279(11):566–570. doi: 10.1056/NEJM196809122791102. [DOI] [PubMed] [Google Scholar]
- Harnden D. G., Elsdale T. R., Young D. E., Ross A. The isolation of cytomegalovirus from peripheral blood. Blood. 1967 Jul;30(1):120–125. [PubMed] [Google Scholar]
- Jack I., Todd H., Turner E. K. Isolation of human cytomegalovirus from the circulating leucocytes of a leukaemic patient. Med J Aust. 1968 Feb 10;1(6):210–213. doi: 10.5694/j.1326-5377.1968.tb28457.x. [DOI] [PubMed] [Google Scholar]
- Lang D. J., Noren B. Cytomegaloviremia following congenital infection. J Pediatr. 1968 Dec;73(6):812–819. doi: 10.1016/s0022-3476(68)80233-1. [DOI] [PubMed] [Google Scholar]
- Lang D. J., Scolnick E. M., Willerson J. T. Association of cytomegalovirus infection with the postperfusion syndrome. N Engl J Med. 1968 May 23;278(21):1147–1149. doi: 10.1056/NEJM196805232782105. [DOI] [PubMed] [Google Scholar]
- MCGAVRAN M. H., SMITH M. G. ULTRASTRUCTURAL, CYTOCHEMICAL, AND MICROCHEMICAL OBSERVATIONS ON CYTOMEGALOVIRUS (SALIVARY GLAND VIRUS) INFECTION OF HUMAN CELLS IN TISSUE CULTURE. Exp Mol Pathol. 1965 Feb;76:1–10. doi: 10.1016/0014-4800(65)90019-5. [DOI] [PubMed] [Google Scholar]
- McMillan G. C. Fatal Inclusion-Disease Pneumonitis in an Adult. Am J Pathol. 1947 Nov;23(6):995–1003. [PMC free article] [PubMed] [Google Scholar]
- Starr J. G., Gold E. Screening of newborn infants for cytomegalovirus infection. J Pediatr. 1968 Dec;73(6):820–824. doi: 10.1016/s0022-3476(68)80234-3. [DOI] [PubMed] [Google Scholar]
- Stulberg C. S., Zuelzer W. W., Page R. H., Taylor P. E., Brough Cytomegalovirus infections with reference to isolations from lymph nodes and blood. Proc Soc Exp Biol Med. 1966 Dec;123(3):976–982. doi: 10.3181/00379727-123-31651. [DOI] [PubMed] [Google Scholar]
- WELLER T. H., HANSHAW J. B. Virologic and clinical observations on cytomegalic inclusion disease. N Engl J Med. 1962 Jun 14;266:1233–1244. doi: 10.1056/NEJM196206142662401. [DOI] [PubMed] [Google Scholar]