Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1970 Mar 28;102(6):602–606.

Negative Pressure Artificial Respiration: Use in Treatment of Respiratory Distress Syndrome of the Newborn

L S Linsao, A Aharon, H Levison, P R Swyer
PMCID: PMC1946605  PMID: 5265798

Abstract

Forty-five newborn infants in respiratory failure with respiratory distress syndrome were treated with intermittent negative pressure ventilation (INPV). There was a survival rate of 38% (17/45).

All infants were initially treated without nasotracheal intubation. However, 24 of these developed a Paco2 greater than 70 mm. Hg and were subsequently intubated. Intubation was followed by a decrease in the degree of hypercarbia in each instance and simultaneous increase in Pao2.

Complications encountered during ventilation were: emphysema (one patient), aspiration pneumonia (two patients), septicemia (two patients), misplaced nasotracheal tube (one patient).

Follow-up of the 17 surviving patients for periods of four to 36 months disclosed two patients with post-intubation hoarseness. One infant initially had spastic quadriplegia with EEG abnormalities, both of which cleared by 5 months of age. In the remaining 14 infants, the results of physical, neurological and psychological examinations have remained within normal limits.

Full text

PDF
602

Images in this article

604FIG. 2
on p.604

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balis J. U., Delivoria M., Conen P. E. Maturation of postnatal human lung and the idiopathic respiratory distress syndrome. Lab Invest. 1966 Mar;15(3):530–546. [PubMed] [Google Scholar]
  2. DELIVORIA-PAPADOPOULOS M., SWYER P. R. ASSISTED VENTILATION IN TERMINAL HYALINE MEMBRANE DISEASE. Arch Dis Child. 1964 Oct;39:481–484. doi: 10.1136/adc.39.207.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DONALD I., KERR M. M., MACDONALD I. R. Respiratory phenomena in the newborn; experiments in their measurement and assistance. Scott Med J. 1958 Apr;3(4):151–164. doi: 10.1177/003693305800300401. [DOI] [PubMed] [Google Scholar]
  4. Delivoria-Papadopoulos M., Levison H., Swyer P. R. Intermittent positive pressure respiration as a treatment in severe respiratory distress syndrome. Arch Dis Child. 1965 Oct;40(213):474–479. doi: 10.1136/adc.40.213.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HANLEY W. B., BRAUDO M., SWYER P. R. NEONATAL RESPIRATORY DISTRESS: EXPERIENCE AT THE HOSPITAL FOR SICK CHILDREN, TORONTO, L960-1961. Can Med Assoc J. 1963 Aug 31;89:375–381. [PMC free article] [PubMed] [Google Scholar]
  6. HEESE H. D., WITTMANN W., MALAN A. F. The management of the respiratory distress syndrome of the newborn with positive-pressure respiration. S Afr Med J. 1963 Jan 19;37:123–126. [PubMed] [Google Scholar]
  7. LEVISON H., DELIVORIA-PAPADOPOULOS M., SWYER P. R. OXYGEN CONSUMPTION IN NEWLY BORN INFANTS WITH THE RESPIRATORY DISTRESS SYNDROME. Biol Neonat. 1964;7:255–269. doi: 10.1159/000239928. [DOI] [PubMed] [Google Scholar]
  8. Levison H., Linsao L., Swyer P. R. A comparison of infra-red and convective heating for newborn infants. Lancet. 1966 Dec 17;2(7477):1346–1348. doi: 10.1016/s0140-6736(66)92088-5. [DOI] [PubMed] [Google Scholar]
  9. Northway W. H., Jr, Rosan R. C., Porter D. Y. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967 Feb 16;276(7):357–368. doi: 10.1056/NEJM196702162760701. [DOI] [PubMed] [Google Scholar]
  10. Owen-Thomas J. B., Ulan O. A., Swyer P. R. The effect of varying inspiratory gas flow rate on arterial oxygenation during IPPV in the respiratory distress syndrome. Br J Anaesth. 1968 Jul;40(7):493–502. doi: 10.1093/bja/40.7.493. [DOI] [PubMed] [Google Scholar]
  11. REID D. H., TUNSTALL M. E. TREATMENT OF RESPIRATORY-DISTRESS SYNDROME OF NEWBORN WITH NASOTRACHEAL INTUBATION AND INTERMITTENT POSITIVE-PRESSURE RESPIRATION. Lancet. 1965 Jun 5;1(7397):1196–1197. doi: 10.1016/s0140-6736(65)92724-8. [DOI] [PubMed] [Google Scholar]
  12. Stahlman M. T., Battersby E. J., Shepard F. M., Blankenship W. J. Prognosis in hyaline-membrane disease. Use of a linear-discriminant. N Engl J Med. 1967 Feb 9;276(6):303–309. doi: 10.1056/NEJM196702092760601. [DOI] [PubMed] [Google Scholar]
  13. Stahlman M. Treatment of cardiovascular disorders of the newborn. Pediatr Clin North Am. 1964 May;11(2):363–400. doi: 10.1016/s0031-3955(16)31554-1. [DOI] [PubMed] [Google Scholar]
  14. THOMAS L. J., Jr, GRIFFO Z. J., ROOS A. Effect of negative-pressure inflation of the lung on pulmonary vascular resistance. J Appl Physiol. 1961 May;16:451–456. doi: 10.1152/jappl.1961.16.3.451. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES