Abstract
Coxsackievirus B4 was isolated from the throat, nose, blood, stools and urine of a 9-year-old boy with acute glomerulonephritis and a pneumonitis. Neutralization test showed a greater than fourfold rise in the antibody titre to coxsackievirus B4. The antistreptolysin O titre was elevated, but the complement component was within the normal range. The importance of the coxsackievirus B4 in the pathogenesis of acute glomerulonephritis is clearly indicated; however, further investigations are needed to understand the details of the virus-kidney interaction.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burch G. E., Chu K. C., Sohal R. S. Glomerulonephritis induced in mice by ECHO 9 virus. N Engl J Med. 1968 Dec 26;279(26):1420–1424. doi: 10.1056/NEJM196812262792603. [DOI] [PubMed] [Google Scholar]
- Burch G. E., Sun S. C., Chu K. C., Sohal R. S., Colcolough H. L. Interstitial and coxsackievirus B myocarditis in infants and children. A comparative histologic and immunofluorescent study of 50 autopsied hearts. JAMA. 1968 Jan 1;203(1):1–8. [PubMed] [Google Scholar]
- Burch G. E., Sun S. C. Viral nephritis. Am Heart J. 1968 Jan;75(1):1–5. doi: 10.1016/0002-8703(68)90110-5. [DOI] [PubMed] [Google Scholar]
- Fish A. J., Herdman R. C., Michael A. F., Pickering R. J., Good R. A. Epidemic acute glomerulonephritis associated with type 49 streptococcal pyoderma. II. Correlative study of light, immunofluorescent and electron microscopic findings. Am J Med. 1970 Jan;48(1):28–39. doi: 10.1016/0002-9343(70)90095-1. [DOI] [PubMed] [Google Scholar]
- Jensen M. M. Viruses and kidney disease. Am J Med. 1967 Dec;43(6):897–911. doi: 10.1016/0002-9343(67)90248-3. [DOI] [PubMed] [Google Scholar]
- Lange K., Treser G., Sagel I., Ty A., Wasserman E. Routine immunohistology in renal diseases. Ann Intern Med. 1966 Jan;64(1):25–40. doi: 10.7326/0003-4819-64-1-25. [DOI] [PubMed] [Google Scholar]
- McCluskey R. T., Vassalli P., Gallo G., Baldwin D. S. An immunofluorescent study of pathogenic mechanisms in glomerular diseases. N Engl J Med. 1966 Mar 31;274(13):695–701. doi: 10.1056/NEJM196603312741301. [DOI] [PubMed] [Google Scholar]