Abstract
A case of Reye's syndrome in a newborn infant, believed to be the first recorded in the perinatal period, is reported. The clinical, biochemical and histological findings are those previously recognized in older infants. The intractable acidosis, hypoglycemia and extreme degree of lactic acidosis reflect an advanced degree of hepatic involvement, probably initiated in utero, with resultant impairment of glycogenolysis and intermediary metabolism.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arnaud C., Maijer R., Reade T., Scriver C. R., Whelan D. T. Vitamin D dependency: an inherited postnatal syndrome with secondary hyperparathyroidism. Pediatrics. 1970 Dec;46(6):871–880. [PubMed] [Google Scholar]
- Bradford W. D., Parker J. C., Jr Reye's syndrome. Possible causes and pathogenetic pathways. Clin Pediatr (Phila) 1971 Mar;10(3):148–153. doi: 10.1177/000992287101000309. [DOI] [PubMed] [Google Scholar]
- De Divitiis O., Giordano F., Gallo B., Jacono A. Tolbutamide and propranolol. Lancet. 1968 Apr 6;1(7545):749–749. doi: 10.1016/s0140-6736(68)92191-0. [DOI] [PubMed] [Google Scholar]
- Gilles F. H., Murphy S. F. Perinatal telencephalic leucoencephalopathy. J Neurol Neurosurg Psychiatry. 1969 Oct;32(5):404–413. doi: 10.1136/jnnp.32.5.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glick T. H., Ditchek N. T., Salitsky S., Freimuth E. J. Acute encephalopathy and hepatic dysfunctionassociated with chickenpox in siblings. Am J Dis Child. 1970 Jan;119(1):68–71. doi: 10.1001/archpedi.1970.02100050070016. [DOI] [PubMed] [Google Scholar]
- HILL K. R., BRAS G., CLEARKIN K. P. Acute toxic hypoglycaemia occurring in the vomiting sickness of Jamaica; morbid anatomical aspects. West Indian Med J. 1955 Jun;4(2):91–104. [PubMed] [Google Scholar]
- Norman M. G. Encephalopathy and fatty degeneration of the viscera in childhood: I. Review of cases at the Hospital for Sick Children, Toronto (1954-1966). Can Med Assoc J. 1968 Sep 28;99(11):522–526. [PMC free article] [PubMed] [Google Scholar]
- Olson L. C., Bourgeois C. H., Jr, Cotton R. B., Harikul S., Grossman R. A., Smith T. J. Encephalopathy and fatty degeneratiof on the viscera in northeastern Thailand. Clinical syndrome and epidemiology. Pediatrics. 1971 Apr;47(4):707–716. [PubMed] [Google Scholar]
- PARR J., TEREE T. M., LARNER J. SYMPTOMATIC HYPOGLYCEMIA, VISCERAL FATTY METAMORPHOSIS, AND AGLYCOGENOSIS IN AN INFANT LACKING GLYCOGEN SYNTHETASE AND PHOSPHORYLAS. Pediatrics. 1965 May;35:770–777. [PubMed] [Google Scholar]
- Peremans J., De Graef P. J., Strubbe G., De Block G. Familial metabolic disorder with fatty metamorphosis of the viscera. J Pediatr. 1966 Dec;69(6):1108–1112. doi: 10.1016/s0022-3476(66)80302-5. [DOI] [PubMed] [Google Scholar]