Abstract
A 50-year-old woman who initially had myasthenia gravis subsequently presented with thymoma, erythroblastopenic anemia and systemic lupus erythematosus during 17 years of follow-up. In a review of the literature no similar documented cases were found, although 14 patients were reported with three of the above diseases, two also having positive LE cell tests. An association of several autoimmune disorders in one patient may be more frequent than was previously believed.
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- CHALMERS J. N. M., BOHEIMER K. Pure red-cell anaemia in patients with thymic tumours. Br Med J. 1954 Dec 25;2(4903):1514–1518. doi: 10.1136/bmj.2.4903.1514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dameshek W., Brown S. M., Rubin A. D. "Pure" red cell anemia (erythroblastic hypoplasia) and thymoma. Semin Hematol. 1967 Jul;4(3):222–232. [PubMed] [Google Scholar]
- Delmas-Marsalet Y., Leduc M., Lerche B., Goudemand M. Tumeur du thymus et lupus érythémateux disséminé. Etude anatomoclinique et considérations physio-pathologiques. Presse Med. 1969 May 3;77(22):821–823. [PubMed] [Google Scholar]
- Field E. O., Caughi M. N., Blackett N. M., Smithers D. W. Marrow-suppressing factors in the blood in pure red-cell aplasia, thymoma and Hodgkin's disease. Br J Haematol. 1968 Jul;15(1):101–110. doi: 10.1111/j.1365-2141.1968.tb01516.x. [DOI] [PubMed] [Google Scholar]
- Fudenberg H. H. Genetically determined immune deficiency as the predisposing cause of "autoimmunity" and lymphoid neoplasia. Am J Med. 1971 Sep;51(3):295–298. doi: 10.1016/0002-9343(71)90263-4. [DOI] [PubMed] [Google Scholar]
- HARVEY A. M., SHULMAN L. E., TUMULTY P. A., CONLEY C. L., SCHOENRICH E. H. Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Baltimore) 1954 Dec;33(4):291–437. [PubMed] [Google Scholar]
- Hirst E., Robertson T. I. The syndrome of thymoma and erythroblastopenic anemia. A review of 56 cases including 3 case reports. Medicine (Baltimore) 1967 May;46(3):225–264. doi: 10.1097/00005792-196705000-00001. [DOI] [PubMed] [Google Scholar]
- Hurd E. R., Dowdle W., Casey H., Ziff M. Virus antibody levels in systemic lupus erythematosus. Arthritis Rheum. 1972 May-Jun;15(3):267–274. doi: 10.1002/art.1780150308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jepson J. H., Lowenstein L. Inhibition of erythropoiesis by a factor present in the plasma of patients with erythroblastopenia. Blood. 1966 Apr;27(4):425–434. [PubMed] [Google Scholar]
- KOUGH R. H., BARNES W. T. THYMOMA ASSOCIATED WITH ERYTHROID APLASIA, BULLOUS SKIN ERUPTION, AND THE LUPUS ERYTHEMATOSUS CELL PHENOMENON; REPORT OF A CASE. Ann Intern Med. 1964 Aug;61:308–315. doi: 10.7326/0003-4819-61-2-308. [DOI] [PubMed] [Google Scholar]
- Knight R. J. Flow-rates through disposable intravenous cannulae. Lancet. 1968 Sep 21;2(7569):665–667. doi: 10.1016/s0140-6736(68)92511-7. [DOI] [PubMed] [Google Scholar]
- MAEKELAE T. E., RUOSTEENOJA R., WAGER O., WALLGREN G. R., JOKINEN E. J. MYASTHENIA GRAVIS AND SYSTEMIC LUPUS ERYTHEMATOSUS. Acta Med Scand. 1964 Jun;175:777–780. doi: 10.1111/j.0954-6820.1964.tb00635.x. [DOI] [PubMed] [Google Scholar]
- ROLAND A. S. THE SYNDROME OF BENIGN THYMOMA AND PRIMARY AREGENERATIVE ANEMIA; AN ANALYSIS OF FORTY-THREE CASES. Am J Med Sci. 1964 Jun;247:719–731. doi: 10.1097/00000441-196406000-00013. [DOI] [PubMed] [Google Scholar]
- Siguier F., Mathé G., Godeau P., Lévy R., Avram C., de Saint-Maur P., Gluckmann E. Erythroblastopénie; myasthénie: cellules de Hargraves; tumeur thymique. Etude d'une observation d'évolution favorable. Ann Med Interne (Paris) 1969 Aug-Sep;120(8):561–568. [PubMed] [Google Scholar]
- Spencer G., Ridley M., Eykyn S., Achong J. Disinfection of lung ventilators by alcohol aerosol. Lancet. 1968 Sep 21;2(7569):667–667. doi: 10.1016/s0140-6736(68)92512-9. [DOI] [PubMed] [Google Scholar]
- Stadtmuller E. S. EXAMINATION OF THE CHILD BEFORE ENTERING SCHOOL. Am J Public Health (N Y) 1926 Jun;16(6):586–589. doi: 10.2105/ajph.16.6.586. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Talal N. Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 1970 Nov-Dec;13(6):887–894. doi: 10.1002/art.1780130620. [DOI] [PubMed] [Google Scholar]
- Thijs L. G., Hijmans W., Leene W., Muntinghe O. G., Pietersz R. N., Ploem J. E. Blast cell leukaemia associated with IgA paraproteinaemia and Bence Jones protein. Br J Haematol. 1970 Oct;19(4):485–492. doi: 10.1111/j.1365-2141.1970.tb06976.x. [DOI] [PubMed] [Google Scholar]
- WEINBAUM J. G., THOMPSON R. F. Erythroblastic hypoplasia associated with thymic tumor and myasthenia gravis; report of a case. Am J Clin Pathol. 1955 Jul;25(7):761–769. doi: 10.1093/ajcp/25.7.761. [DOI] [PubMed] [Google Scholar]






