Abstract
A report is presented of a patient surviving four years with a human cardiac allograft. The allograft arteries showed marked graft arteriosclerosis with intimal fibrocellular proliferation. The arteriosclerotic lesions occurring in the larger epicardial vessels were strikingly similar to spontaneous atherosclerosis. The relationship of the long-term survival to the use of a permanent transvenous pacemaker and of the development of severe vascular lesions to acute rejection and hyperlipemia are discussed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bieber C. P., Stinson E. B., Shumway N. E., Payne R., Kosek J. Cardiac transplantation in man. VII. Cardiac allograft pathology. Circulation. 1970 May;41(5):753–772. doi: 10.1161/01.cir.41.5.753. [DOI] [PubMed] [Google Scholar]
- Billingham M. E., Caves P. K., Dong E., Jr, Shumway N. E. The diagnosis of canine orthotopic cardiac allograft rejection by transvenous endomyocardial biopsy. Transplant Proc. 1973 Mar;5(1):741–743. [PubMed] [Google Scholar]
- Cannom D. S., Graham A. F., Harrison D. C. Electrophysiological studies in the denervated transplanted human heart. Response to trial pacing and atropine. Circ Res. 1973 Feb;32(2):268–278. doi: 10.1161/01.res.32.2.268. [DOI] [PubMed] [Google Scholar]
- Clark D. A., Schroeder J. S., Griepp R. B., Stinson E. B., Dong E., Shumway N. E., Harrison D. C. Cardiac transplantation in man. Review of first three years' experience. Am J Med. 1973 May;54(5):563–576. doi: 10.1016/0002-9343(73)90114-9. [DOI] [PubMed] [Google Scholar]
- Henson D. E., Najafi H., Callaghan R., Coogan P., Julian O. C., Eisenstein R. Myocardial lesions following open heart surgery. Arch Pathol. 1969 Oct;88(4):423–430. [PubMed] [Google Scholar]
- Kosek J. C., Bieber C., Lower R. R. Heart graft arteriosclerosis. Transplant Proc. 1971 Mar;3(1):512–514. [PubMed] [Google Scholar]
- Kosek J. C., Chartrand C., Hurley E. J., Lower R. R. Arteries in canine cardiac homografts. Ultrastructure during acute rejection. Lab Invest. 1969 Oct;21(4):328–335. [PubMed] [Google Scholar]
- Kosek J. C., Hurley E. J., Lower R. R. Histopathology of orthotopic canine cardiac homografts. Lab Invest. 1968 Jul;19(1):97–112. [PubMed] [Google Scholar]
- PORTER K. A., PEART W. S., KENYON J. R., JOSEPH N. H., HOEHN R. J., CALNE R. Y. REJECTION OF KIDNEY HOMOTRANSPLANTS. Ann N Y Acad Sci. 1964 Nov 30;120:472–495. doi: 10.1111/j.1749-6632.1964.tb34746.x. [DOI] [PubMed] [Google Scholar]
- SCHLESINGER M. J. New radiopaque mass for vascular injection. Lab Invest. 1957 Jan-Feb;6(1):1–11. [PubMed] [Google Scholar]
- Thomson J. G. Production of severe atheroma in a transplanted human heart. Lancet. 1969 Nov 22;2(7630):1088–1092. doi: 10.1016/s0140-6736(69)90700-4. [DOI] [PubMed] [Google Scholar]