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. 1974 May 18;110(10):1182–1185.

Percutaneous absorption

Paul Brisson
PMCID: PMC1947480  PMID: 4597976

Abstract

Clinical effectiveness of topically applied medications depends on the ability of the active ingredient to leave its vehicle and penetrate into the epidermis. The stratum corneum is that layer of the epidermis which functionally is the most important in limiting percutaneous absorption, showing the characteristics of a composite semipermeable membrane. A mathematical expression of transepidermal diffusion may be derived from Fick's Law of mass transport; factors altering the rate of diffusion are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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