Abstract
The Guillain-Barré syndrome is hypothesized to be secondary to cellular hypersensitivity to peripheral nerve antigens. To test this theory lymphocytes from 100 subjects were studied using the macrophage-migration-inhibition factor (MIF) assay. Thirty-four normal controls gave a mean migration of 100.4 ± 9%. Of 34 patients with peripheral nervous system disease, only those with the Guillain-Barré syndrome showed hypersensitivity with a mean migration of 72 ± 11%. Of 34 patients with central nervous system disease only three with multiple sclerosis and two with stroke gave similar results. Positive results in the Guillain-Barré syndrome were found only in patients presenting with classical disease and who were ill at the time of study.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arnason B. G., Winkler G. F., Hadler N. M. Cell-mediated demyelination of peripheral nerve in tissue culture. Lab Invest. 1969 Jul;21(1):1–10. [PubMed] [Google Scholar]
- Asbury A. K., Arnason B. G., Adams R. D. The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis. Medicine (Baltimore) 1969 May;48(3):173–215. doi: 10.1097/00005792-196905000-00001. [DOI] [PubMed] [Google Scholar]
- DAVID J. R., AL-ASKARI S., LAWRENCE H. S., THOMAS L. DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. J Immunol. 1964 Aug;93:264–273. [PubMed] [Google Scholar]
- David J. R., Paterson P. Y. In vitro demonstration of cellular sensitivity in allergic encephalomyelitis. J Exp Med. 1965 Dec 1;122(6):1161–1171. doi: 10.1084/jem.122.6.1161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- David J. R., Schlossman S. F. Immunochemical studies on the specificity of cellular hypersensitivity. The in vitro inhibition of peritoneal exudate cell migration by cehmically defined antigens. J Exp Med. 1968 Dec 1;128(6):1451–1459. doi: 10.1084/jem.128.6.1451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rocklin R. E. Production of migration inhibitory factor by non-dividing lymphocytes. J Immunol. 1973 Mar;110(3):674–678. [PubMed] [Google Scholar]
- Rocklin R. E., Sheremata W. A., Feldman R. G., Kies M. W., David J. R. The Guillain-Barré syndrome and multiple sclerosis. In vitro cellular responses to nervous-tissue antigens. N Engl J Med. 1971 Apr 15;284(15):803–808. doi: 10.1056/NEJM197104152841501. [DOI] [PubMed] [Google Scholar]
- Sheremata W. A., Behan P. O. Experimental allergic neuritis: a new experimental approach. J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):139–145. doi: 10.1136/jnnp.36.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thor D. E., Jureziz R. E., Veach S. R., Miller E., Dray S. Cell migration inhibition factor released by antigen from human peripheral lymphocytes. Nature. 1968 Aug 17;219(5155):755–757. doi: 10.1038/219755a0. [DOI] [PubMed] [Google Scholar]
- WAKSMAN B. H., ADAMS R. D. Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J Exp Med. 1955 Aug 1;102(2):213–236. doi: 10.1084/jem.102.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]