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. 1974 Jul 6;111(1):51–53.

Athyreotic cretinism associated with thymic hypoplasia and amyloidosis of lymphoid tissue

W E DeCoteau, Fergus A Murphy, J W Gerrard
PMCID: PMC1947565  PMID: 4601509

Abstract

A child presenting at 5 months of age with Hemophilus influenzae meningitis was also found to be severely hypothyroid. The child died two years later from the complications of measles pneumonia. At autopsy, no thyroid tissue was found and the thymus was hypoplastic. Most of the lymphoid tissues were infiltrated by amyloid.

It is possible that there was a combined developmental defect involving thyroid and thymus. The alternatives are that the association occurred purely by chance or that the severe hypothyroid state led to thymic insufficiency.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hong R., Gatti R., Rathbun J. C., Good R. A. Thymic hypoplasia and thyroid dysfunction. N Engl J Med. 1970 Feb 26;282(9):470–474. doi: 10.1056/NEJM197002262820903. [DOI] [PubMed] [Google Scholar]
  2. Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann Intern Med. 1972 Oct;77(4):605–628. [PubMed] [Google Scholar]
  3. Kirkpatrick C. H., Rich R. R., Bennett J. E. Chronic mucocutaneous candidiasis: model-building in cellular immunity. Ann Intern Med. 1971 Jun;74(6):955–978. doi: 10.7326/0003-4819-74-6-955. [DOI] [PubMed] [Google Scholar]
  4. Ranlov P. The role of the thymus in experimental mouse amyloidosis. Acta Pathol Microbiol Scand. 1966;67(1):42–54. doi: 10.1111/apm.1966.67.1.42. [DOI] [PubMed] [Google Scholar]
  5. Sutherland D. E., Archer O. K., Peterson R. D., Eckert E., Good R. A. Development of "autoimmune processes" in rabbits after neonatal removal of central lymphoid tissue. Lancet. 1965 Jan 16;1(7377):130–133. doi: 10.1016/s0140-6736(65)91091-3. [DOI] [PubMed] [Google Scholar]

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