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. 1963 Feb;42(2):201–223.

Complement Fixation in Diseased Tissues

II. Fixation of Guinea Pig Complement in Renal Lesions of Systemic Lupus Erythematosus

Peter M Burkholder
PMCID: PMC1949634  PMID: 14017061

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURKHOLDER P. M., LITTELL A. H., KLEIN P. G. Sectioning at room temperature of unfixed tissues, frozen in a gelatin matrix, for immunohistologic procedures. Stain Technol. 1961 Mar;36:89–91. doi: 10.3109/10520296109113250. [DOI] [PubMed] [Google Scholar]
  2. DAMESHEK W. Systemic lupus erythematosus: a complex auto-immune disorder. Ann Intern Med. 1958 Apr;48(4):707–730. doi: 10.7326/0003-4819-48-4-707. [DOI] [PubMed] [Google Scholar]
  3. DOMZ C. A., McNAMARA D. H., HOLZAPFEL H. F. Tetracycline provocation in lupus erythematosus. Ann Intern Med. 1959 May;50(5):1217–1226. doi: 10.7326/0003-4819-50-5-1217. [DOI] [PubMed] [Google Scholar]
  4. FREEDMAN P., MARKOWITZ A. S. Gamma globulin and complement in the diseased kidney. J Clin Invest. 1962 Feb;41:328–334. doi: 10.1172/JCI104486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FREEDMAN P., PETERS J. H., KARK R. M. Localization of gamma-globulin in the diseased kidney. Arch Intern Med. 1960 Apr;105:524–535. doi: 10.1001/archinte.1960.00270160022005. [DOI] [PubMed] [Google Scholar]
  6. GOLD S. Role of sulphonamides and penicillin in the pathogenesis of systemic lupus erythematosus. Lancet. 1951 Feb 3;1(6649):268–272. doi: 10.1016/s0140-6736(51)93319-3. [DOI] [PubMed] [Google Scholar]
  7. HARVEY A. M., SHULMAN L. E., TUMULTY P. A., CONLEY C. L., SCHOENRICH E. H. Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Baltimore) 1954 Dec;33(4):291–437. [PubMed] [Google Scholar]
  8. ISHIZAKA T., ISHIZAKA K. Biological activities of aggregated gamma globulin. I. Skin reactive and complement-fixing properties of heat denatured gamma globulin. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:845–850. doi: 10.3181/00379727-101-25116. [DOI] [PubMed] [Google Scholar]
  9. KLEIN P. G., BURKHOLDER P. M. Studies on the antigenic properties of complement. I. Demonstration of agglutinating antibodies against guinea pig complement fixed on sensitized sheep erythrocytes. J Exp Med. 1960 Jan 1;111:93–106. doi: 10.1084/jem.111.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KLEIN P. G., BURKHOLDER P. M. Studies on the antigenic properties of complement. II. Analysis of specific agglutinins against certain components of guinea pig complement fixed on sensitized sheep erythrocytes. J Exp Med. 1960 Jan 1;111:107–117. doi: 10.1084/jem.111.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KLEIN P. G. Studies on immune hemolysis: preparation of a stable and highly reactive complex of sensitized erythrocytes and the first component of complement (EAC'1): inactivation of cell-fixed C'1 by some complement reagents. J Exp Med. 1960 Jan 1;111:77–91. doi: 10.1084/jem.111.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KLEIN P., BURKHOLDER P. [A method for fluorescence-optic demonstration of complement fixation and its use in the histo-immunological demonstration of experimental kidney anaphylaxis]. Dtsch Med Wochenschr. 1959 Nov 6;84:2001–2004. doi: 10.1055/s-0028-1114563. [DOI] [PubMed] [Google Scholar]
  13. LACHMANN P. J., MULLER-EBERHARD H. J., KUNKEL H. G., PARONETTO F. The localization of in vivo bound complement in tissue section. J Exp Med. 1962 Jan 1;115:63–82. doi: 10.1084/jem.115.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LANGE K., WASSERMAN E., SLOBODY L. B. The significance of serum complement levels for the diagnosis and prognosis of acute and subacute glomerulonephritis and lupus erythematosus disseminatus. Ann Intern Med. 1960 Oct;53:636–646. doi: 10.7326/0003-4819-53-4-636. [DOI] [PubMed] [Google Scholar]
  15. MELLORS R. C., ORTEGA L. G., HOLMAN H. R. Role of gamma globulins in pathogenesis of renal lesions in systemic lupus erythematosus and chronic membranous glomerulonephritis, with an observation on the lupus erythematosus cell reaction. J Exp Med. 1957 Aug 1;106(2):191–202. doi: 10.1084/jem.106.2.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. ROBBINS W. C., HOLMAN H. R., DEICHER H., KUNKEL H. G. Complement fixation with cell nuclei and DNA in lupus erythematosus. Proc Soc Exp Biol Med. 1957 Dec;96(3):575–579. doi: 10.3181/00379727-96-23545. [DOI] [PubMed] [Google Scholar]
  17. VAZQUEZ J. J., DIXON F. J. Immunohistochemical study of lesions in rheumatic fever, systemic lupus ervthematosus, and rheumatoid arthritis. Lab Invest. 1957 May-Jun;6(3):205–217. [PubMed] [Google Scholar]
  18. WEIGLE W. O., MAURER P. H. The effect of complements on soluble antigen-antibody complexes. J Immunol. 1957 Sep;79(3):211–222. [PubMed] [Google Scholar]
  19. WEIGLE W. O., MAURER P. H. Transfer of complement from on antigen-antibody complex to another. Proc Soc Exp Biol Med. 1957 Nov;96(2):371–376. doi: 10.3181/00379727-96-23481. [DOI] [PubMed] [Google Scholar]

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