Table 3.
Characteristics of Steroid “Deltas” and Peaks
| 3a Delta Values following ACTH stimulation (difference between baseline steroid value and value at peak*, difference between baseline and 30 minute value**, difference between baseline and 60 minute value***) | ||
|---|---|---|
| STEROID | Normal subjects | Subjects with AI |
| Peak Delta* (mean ± SE) | Peak Delta* (mean ± SE) | |
| Cortisol (μg/dL) | 19.6 ± 6.6 | 5.7 ± 4.5 |
| Aldosterone (ng/dL) | 7.8 ± 5.5 | 6.4 ± 5.5 |
| 11-deoxycortisol (ng/dL) | 579.5 ± 264.8 | 177.2 ± 127.0 |
| DHEA (μg/dL) | 358.4 ± 260.8 | 43.4 ± 69.5 |
| 17-hydroxyprogesterone (ng/dL) | 119.8 ± 157.6 | 88.4 ± 124.5 |
| Androstenedione (ng/mL) | 0.4 ± 0.3 | 0.1 ± 0.2 |
| DHEA-S (μg/dL) | 17.0 ± 22.6 | 7.7 ± 12.1 |
| 30 minute Delta** (mean ± SE) | 30 minute Delta** (mean ± SE) | |
| Cortisol (μg/dL) | 15.1 ± 4.9 | 4.2 ± 3.8 |
| Aldosterone (ng/dL) | 7.3 ± 5.7 | 5.8 ± 5.9 |
| 11-deoxycortisol (ng/dL) | 492.5 ± 245.7 | 143.6 ± 107.6 |
| DHEA (μg/dL) | 287.7 ± 226.7 | 10.0 ± 57.1 |
| 60 minute Delta*** (mean ± SE) | 60 minute Delta*** (mean ± SE) | |
| Cortisol (μg/dL) | 19.6 ± 6.6 | 5.6 ± 4.9 |
| Aldosterone (ng/dL) | 4.8 ± 4.5 | 4.9 ± 5.8 |
| 11-deoxycortisol (ng/dL) | 591.5 ± 268.4 | 164.0 ± 131.3 |
| DHEA (μg/dL) | 344.6 ± 262.6 | 21.2 ± 103.7 |
| 3b Distribution of Steroid Peaks following ACTH injection in normal subjects | ||
| STEROID | Peak at 30 minutes (%) | Peak at 60 minutes (%) |
| Cortisol | 2 | 98 |
| Aldosterone | 73 | 27 |
| 11-deoxycortisol | 15 | 85 |
| DHEA | 28 | 72 |
| 17-hydroxyprogesterone | 36 | 64 |
| Androstenedione | 36 | 64 |
| DHEA-S | 23 | 77 |
| 3c Correlation between peak cortisol values and peak values of other steroids | ||
| STEROID | Correlation coefficient using all subjects | Correlation coefficient for subjects excluding secondary AI |
| Aldosterone | 0.19 | 0.37 |
| 11-deoxycortisol | 0.67 | 0.59 |
| DHEA | 0.48 | 0.38 |
| 17-hydroxyprogesterone | 0.26 | 0.25 |
| Androstenedione | 0.41 | 0.37 |
| DHEA-S | 0.33 | 0.18 |