Table 2 Rapid and early decrease of HCV RNA by response and group of treatment (n = 323).
| IFN α2b+ribavirin group | PEG‐IFN α2b+ribavirin group | |||||||
|---|---|---|---|---|---|---|---|---|
| n | ΔD0–W2 (SD) | ΔD0–W4 (SD) | ΔD0–W12 (SD) | n | ΔD0–W2 (SD) | ΔD0–W4 (SD) | ΔD0–W12 (SD) | |
| SVR | 39 | 2.13 (1.02) | 3.18 (0.94) | 4.10 (0.95) | 49 | 2.26 (1.11) | 2.99 (1.32) | 3.97 (0.95) |
| *p = 0.24 | *p = 0.012 | *p = 0.09 | *p = 0. 09 | *p = 0.59 | *p = 0.63 | |||
| RR | 8 | 1.35 (0.42) | 2.60 (0.53) | 3.69 (0.70) | 18 | 1.05 (0.70) | 1.78 (1.27) | 3.41 (1.02) |
| †p = 0.03 | †p = 0.05 | †p = 0.16 | †p<0.01 | †p<0.01 | †p = 0.04 | |||
| RB | 14 | 1.74 (0.72) | 2.26 (1.15) | 3.52 (1.15) | 13 | 1.75 (0.79) | 2.83 (1.23) | 4.05 (1.08) |
| ‡p = 0.25 | ‡p = 0.77 | ‡p = 0.83 | ‡p = 0.018 | ‡p = 0.037 | ‡p = 0.11 | |||
| NR | 103 | 0.55 (0.55) | 0.74 (0.79) | 1.00 (1.00) | 79 | 0.73 (0.94) | 0.95 (0.96) | 1.21 (1.38) |
| §p<0.01 | §p<0.01 | §p<0.01 | §p = 0.03 | §p<0.01 | §p<0.01 | |||
Data are expressed as log HCV RNA load decline in serum samples at W2, W4 and W12 compared to viral load at baseline (day 0), with mean value and 95% confidence intervals for each treatment group and response.
*Responders with breakthrough (RB) compared to sustained virological responders (SVR); †relapsers (RR) compared to SVR; ‡RB compared to RR; §non‐responders (NR) compared to RR. p Value is not significant if p>0.05.