Abstract
Trimethoprim-sulfamethoxazole (TMP-SMX) caused no significant changes in the blood glucose or insulin concentrations of diabetic subjects treated by dietary measures alone or by insulin and diet. In only one of eight subjects receiving oral hypoglycemic agents for the control of diabetes did a significant immediate increase in immunoreactive insulin follow administration of TMP-SMX. In the same patient hypoglycemic symptoms were present after the agent had been taken for 14 days.
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- CHRISTENSEN L. K., HANSEN J. M., KRISTENSEN M. SULPHAPHENAZOLE-INDUCED HYPOGLYCAEMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS. Lancet. 1963 Dec 21;2(7321):1298–1301. doi: 10.1016/s0140-6736(63)90847-x. [DOI] [PubMed] [Google Scholar]
- GULBRANDSEN R. [Potentiation of tolbutamide by phenylbutazone]. Tidsskr Nor Laegeforen. 1959 Oct 1;79:1127–1128. [PubMed] [Google Scholar]
- PFEIFFER E. F., PFEIFFER M., DITSCHUNEIT H., AHN C. S. Clinical and experimental studies of insulin secretion following tolbutamide and metahexamide administration. Ann N Y Acad Sci. 1959 Sep 25;82:479–495. doi: 10.1111/j.1749-6632.1959.tb44927.x. [DOI] [PubMed] [Google Scholar]
- SCHAMBYE P., TARDING F. Changes induced by insulin and tolbutamide in the glucose output of the liver. Ann N Y Acad Sci. 1959 Mar 30;74(3):557–569. doi: 10.1111/j.1749-6632.1959.tb39580.x. [DOI] [PubMed] [Google Scholar]
- SCHOLTAN W. [The binding of long-acting sulfonamides on serum proteins. 2]. Arzneimittelforschung. 1961 Aug;11:707–720. [PubMed] [Google Scholar]
- WISHINSKY H., GLASSER E. J., PERKAL S. Protein interactions of sulfonylurea compounds. Diabetes. 1962;11(Suppl):18–25. [PubMed] [Google Scholar]