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. 1975 Nov 22;113(10):941–944.

Analysis of a measles epidemic; possible role of vaccine failures.

W E Rawls, M L Rawls, M A Chernesky
PMCID: PMC1956577  PMID: 1192310

Abstract

A measles epidemic occurred in the Greensville (Ont.) Unit schools during January and February 1975. There were 47 cases of measles in 403 students: 26 (55%) of the children had a history of being vaccinated and 18 (38%) had not been vaccinated. Among children known to have been vaccinated at less than 1 year of age 7 of 13 contracted measles, while among the 48 children who had not been vaccinated 18 contracted measles. The attack rate among vaccinees increased with increasing time since vaccination. The observations of this study as well as those of similar studies suggest that vaccine failures contributed to the genesis of the epidemic. It is recommended that all children initially vaccinated at less than 1 year of age should be revaccinated with live attenuated measles virus vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER E. R., BANSMER C. M., HARRIS E. S., GILES B., SPARKS M. J. MEASLES VACCINATION IN INFANTS. USE OF KILLED-LIVE COMBINATIONS. Am J Dis Child. 1964 Nov;108:470–478. doi: 10.1001/archpedi.1964.02090010472005. [DOI] [PubMed] [Google Scholar]
  2. Arbeter A. M., Arthur J. H., Blakeman G. J., McIntosh K. Measles immunity: reimmunization of children who previously received live measles vaccine and gamma globulin. J Pediatr. 1972 Oct;81(4):737–741. doi: 10.1016/s0022-3476(72)80094-5. [DOI] [PubMed] [Google Scholar]
  3. Baratta R. O., Ginter M. C., Price M. A., Walker J. W., Skinner R. G., Prather E. C., David J. K. Measles (rubeola) in previously immunized children. Pediatrics. 1970 Sep;46(3):397–402. [PubMed] [Google Scholar]
  4. Barsky P. Measles: Winnipeg, 1973. Can Med Assoc J. 1974 Apr 20;110(8):931–934. [PMC free article] [PubMed] [Google Scholar]
  5. Brown P., Gajdusek D. C., Tsai T. Persistence of measles antibody in the absence of circulating natural virus five years after immunization of an isolated virgin population with Edmonston B vaccine. Am J Epidemiol. 1969 Dec;90(6):514–518. doi: 10.1093/oxfordjournals.aje.a121097. [DOI] [PubMed] [Google Scholar]
  6. CHRISTENSEN P. E., SCHMIDT H., JENSEN O., BANG H. O., ANDERSEN V., JORDAL B. An epidemic of measles in Southern Greenland, 1951. I. Measles in virgin soil. Acta Med Scand. 1953;144(4):313–322. doi: 10.1111/j.0954-6820.1953.tb15701.x. [DOI] [PubMed] [Google Scholar]
  7. Cherry J. D., Feigin R. D., Lobes L. A., Jr, Hinthorn D. R., Shackelford P. G., Shirley R. H., Lins R. D., Choi S. C. Urban measles in the vaccine era: a clinical, epidemiologic, and serologic study. J Pediatr. 1972 Aug;81(2):217–230. doi: 10.1016/s0022-3476(72)80287-7. [DOI] [PubMed] [Google Scholar]
  8. Cherry J. D., Feigin R. D., Shackelford P. G., Hinthorn D. R., Schmidt R. R. A clinical and serologic study of 103 children with measles vaccine failure. J Pediatr. 1973 May;82(5):802–808. doi: 10.1016/s0022-3476(73)80070-8. [DOI] [PubMed] [Google Scholar]
  9. Conrad J. L., Wallace R., Witte J. J. The epidemiologic rationale for the failure to eradicate measles in the United States. Am J Public Health. 1971 Nov;61(11):2304–2310. doi: 10.2105/ajph.61.11.2304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Currier R. W., 2nd, Hardy G. E., Jr, Conrad J. L. Measles in previously vaccinated children. Evaluation of an outbreak. Am J Dis Child. 1972 Dec;124(6):854–857. doi: 10.1001/archpedi.1972.02110180056007. [DOI] [PubMed] [Google Scholar]
  11. Hardy G. E., Jr, Kassanoff I., Orbach H. G., Case G. E., Witte J. J. The failure of a school immunization campaign to terminate an urban epidemic of measles. Am J Epidemiol. 1970 Mar;91(3):286–293. doi: 10.1093/oxfordjournals.aje.a121138. [DOI] [PubMed] [Google Scholar]
  12. Horwitz O., Grünfeld K., Lysgaard-Hansen B., Kjeldsen K. The epidemiology and natural history of measles in Denmark. Am J Epidemiol. 1974 Aug;100(2):136–149. doi: 10.1093/oxfordjournals.aje.a112016. [DOI] [PubMed] [Google Scholar]
  13. Imperato P. J., Pincus L., Hwa C. L., Chaves A. D. The control of measles in New York City. Bull N Y Acad Med. 1974 May;50(5):602–619. [PMC free article] [PubMed] [Google Scholar]
  14. KATZ S. L., ENDERS J. F., HOLLOWAY A. Use of Edmonston attenuated measles strain. A summary of three years' experience. Am J Dis Child. 1962 Mar;103:340–344. doi: 10.1001/archpedi.1962.02080020352031. [DOI] [PubMed] [Google Scholar]
  15. KRUGMAN S., GILES J. P., FRIEDMAN H., STONE S. STUDIES ON IMMUNITY TO MEASLES. J Pediatr. 1965 Mar;66:471–488. doi: 10.1016/s0022-3476(65)80112-3. [DOI] [PubMed] [Google Scholar]
  16. Linnemann C. C., Jr Measles vaccine: immunity, reinfection and revaccination. Am J Epidemiol. 1973 Jun;97(6):365–371. doi: 10.1093/oxfordjournals.aje.a121517. [DOI] [PubMed] [Google Scholar]
  17. Linnemann C. C., Jr, Rotte T. C., Schiff G. M., Youtsey J. L. A seroepidemiologic study of a measles epidemic in a highly immunized population. Am J Epidemiol. 1972 Mar;95(3):238–246. doi: 10.1093/oxfordjournals.aje.a121391. [DOI] [PubMed] [Google Scholar]
  18. Nelson K. E., Kallick C. A., Resnick L., Kallick S., Gotoff S. P., Levin S. Current strategy for urban measles control. An evaluation. JAMA. 1974 Feb 18;227(7):780–783. [PubMed] [Google Scholar]
  19. O'Neil A. E. The measles epidemic in Calgary 1969-70; the protective effect of vaccination for the individual and the community. Can Med Assoc J. 1971 Oct 23;105(8):819–825. [PMC free article] [PubMed] [Google Scholar]
  20. Plotkin S. A. Failures of protection by measles vaccine. J Pediatr. 1973 May;82(5):908–911. doi: 10.1016/s0022-3476(73)80107-6. [DOI] [PubMed] [Google Scholar]
  21. REILLY C. M., STOKES J., Jr, BUYNAK E. B., GOLDNER H., HILLEMAN M. R. Living attenuated measles-virus vaccine in early infancy. Studies of the role of passive antibody in immunization. N Engl J Med. 1961 Jul 27;265:165–169. doi: 10.1056/NEJM196107272650403. [DOI] [PubMed] [Google Scholar]
  22. Reynolds D. W., Start A. Immunity to measles in children vaccinated before and after 1 year of age. Am J Dis Child. 1972 Dec;124(6):848–850. doi: 10.1001/archpedi.1972.02110180050006. [DOI] [PubMed] [Google Scholar]
  23. Schluederberg A., Lamm S. H., Landrigan P. J., Black F. L. Measles immunity in children vaccinated before one year of age. Am J Epidemiol. 1973 Jun;97(6):402–409. doi: 10.1093/oxfordjournals.aje.a121521. [DOI] [PubMed] [Google Scholar]
  24. Schreier H. A. On the failure to eradicate measles. N Engl J Med. 1974 Apr 4;290(14):803–804. doi: 10.1056/NEJM197404042901412. [DOI] [PubMed] [Google Scholar]
  25. Warin J. F., Harker P., Mayon-White R. T. Measles in vaccinated children in Oxford 1971. Lancet. 1972 Oct 14;2(7781):810–812. doi: 10.1016/s0140-6736(72)92162-9. [DOI] [PubMed] [Google Scholar]
  26. Wyll S. A., Witte J. J. Measles in previously vaccinated children. An epidemiological study. JAMA. 1971 May 24;216(8):1306–1310. [PubMed] [Google Scholar]

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