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. 1975 Sep 20;113(6):517–520.

Effect of chronic renal failure, dialysis and transplantation on motor nerve conduction velocity in children.

G S Arbus, N A Barnor, A C Hsu, E G Murphy, I C Radde
PMCID: PMC1956736  PMID: 1098759

Abstract

Ulnar and peroneal motor nerve conduction volocities (MNCVs) were measured in 47 children in a dialysis-transplantation program. Mean peroneal MNCV was significantly decreased from normal in children with mild renal failure (serum creatinine concentration, 1.5 to 2.9 mg/dl), whereas ulnar MNCV was significantly decreased only when the serum creatinine value was at least 9 mg/dl. Both ulnar and peroneal MNCVs remained unchanged during long-term hemodialysis or peritoneal dialysis; however, after individual dialyses ulnar MNCV increased. After renal transplantation ulnar MNCV returned to normal within a year and peroneal MNCV within 3 years. Before dialysis was required and during long-term dialysis most plasma magnesium values were elevated; ionized calcium activity was decreased in about 50% of determinations. After transplantation and the concentration of divalent cations rapidly returned to normal. These children differed from adults studied in that (a) there was no correlation between severity of renal failure and MNCV, (b) long-term dialysis did not improve MNCV and (c) peroneal velocities did not recover for 3 years after transplantation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALCOCK N., MACINTYRE I., RADDE I. The determination of magnesium in biological fluids and tissues by flame spectrophotometry. J Clin Pathol. 1960 Nov;13:506–510. doi: 10.1136/jcp.13.6.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blagg C. R., Kemble F., Taverner D. Nerve conduction velocity in relationship to the severity of renal disease. Nephron. 1968;5(4):290–299. doi: 10.1159/000179638. [DOI] [PubMed] [Google Scholar]
  3. Bolton C. F., Baltzan M. A., Baltzan R. B. Effects of renal transplantation on uremic neuropathy. A clinical and electrophysiologic study. N Engl J Med. 1971 May 27;284(21):1170–1175. doi: 10.1056/NEJM197105272842102. [DOI] [PubMed] [Google Scholar]
  4. Codish S. D., Cress R. H. Motor and sensory nerve conduction in uremic patients undergoing repeated dialysis. Arch Phys Med Rehabil. 1971 Jun;52(6):260–263. [PubMed] [Google Scholar]
  5. Curtis J. R., Eastwood J. B., Smith E. K., Storey J. M., Verroust P. J., de Wardener H. E., Wing A. J., Wolfson E. M. Maintenance haemodialysis. Q J Med. 1969 Jan;38(149):49–89. [PubMed] [Google Scholar]
  6. Fleming L. W., Lenman J. A., Stewart W. K. Effect of magnesium on nerve conduction velocity during regular dialysis treatment. J Neurol Neurosurg Psychiatry. 1972 Jun;35(3):342–355. doi: 10.1136/jnnp.35.3.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Honet J. C., Jebsen R. H., Tenckhoff H. A., McDonald J. R. Motor nerve conduction velocity in chronic renal insufficiency. Arch Phys Med Rehabil. 1966 Oct;47(10):647–652. [PubMed] [Google Scholar]
  8. Ibrahim M. M., Barnes A. D., Crosland J. M., Dawson-Edwards P., Honigsberger L., Newman C. E., Robinson B. H. Effect of renal transplantation of uraemic neuropathy. Lancet. 1974 Sep 28;2(7883):739–742. doi: 10.1016/s0140-6736(74)90939-8. [DOI] [PubMed] [Google Scholar]
  9. Jebsen R. H., Tenckhoff H., Honet J. C. Natural history of uremic polyneuropathy and effects of dialysis. N Engl J Med. 1967 Aug 17;277(7):327–333. doi: 10.1056/NEJM196708172770702. [DOI] [PubMed] [Google Scholar]
  10. Jennekens F. G., Mees E. J., Most van Spijk D van Clinical aspects of uraemic polyneuropathy. Nephron. 1971;8(5):414–426. [PubMed] [Google Scholar]
  11. MACINTYRE I. Flame photometry. Adv Clin Chem. 1961;4:1–28. [PubMed] [Google Scholar]
  12. Marcus J., Ehrlich R., Kelly M., Murphy E. G. Nerve conduction in childhood diabetes. Can Med Assoc J. 1973 May 5;108(9):1116–1119. [PMC free article] [PubMed] [Google Scholar]
  13. McVicar M., Gauthier B., Goodman C. T. Uremic neuropathy. Monitoring of transketolase activity inhibition in a child. Am J Dis Child. 1973 Feb;125(2):263–265. doi: 10.1001/archpedi.1973.04160020079016. [DOI] [PubMed] [Google Scholar]
  14. PRESWICK G., JEREMY D. SUBCLINICAL POLYNEUROPATHY IN RENAL INSUFFICIENCY. Lancet. 1964 Oct 3;2(7362):731–732. doi: 10.1016/s0140-6736(64)92548-6. [DOI] [PubMed] [Google Scholar]
  15. Radde I. C., Höffken B., Parkinson D. K., Sheepers J., Luckham A. Practical aspects of a measurement technique for calcium ion activity in plasma. Clin Chem. 1971 Oct;17(10):1002–1006. [PubMed] [Google Scholar]
  16. TENCKHOFF H. A., BOEN S. T., JEBSEN R. H., SPIEGLER J. H. POLYNEUROPATHY IN CHRONIC RENAL INSUFFICIENCY. JAMA. 1965 Jun 28;192:1121–1124. doi: 10.1001/jama.1965.03080260009003. [DOI] [PubMed] [Google Scholar]
  17. Tyler H. R. Neurologic disorders in renal failure. Am J Med. 1968 May;44(5):734–748. doi: 10.1016/0002-9343(68)90255-6. [DOI] [PubMed] [Google Scholar]

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