Abstract
Of 35 newborn infants who died from an infection 19 had postmortem evidence of massive pulmonary hemorrhage. All but 1 of the 19 had evidence of antimortem formation of intravascular fibrin clots in lung tissue. Seventeen infants had low platelet counts. Of the 11 infants in whom coagulation studies were done, 8 had evidence of disseminated intravascular coagulation (DIC) during life. Vasculitis in the lungs, associated with fibrin clots and hemorrhages, was detected in two infants. It is postulated that sepsis is an important cause of hemorrhage in the newborn, probably as a result of the development of DIC.
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- AHVENAINEN E. K., CALL J. D. Pulmonary hemorrhage in infants; a descriptive study. Am J Pathol. 1952 Jan-Feb;28(1):1–23. [PMC free article] [PubMed] [Google Scholar]
- Abildgaard C. F. Recognition and treatment of intravascular coagulation. J Pediatr. 1969 Feb;74(2):163–176. doi: 10.1016/s0022-3476(69)80064-8. [DOI] [PubMed] [Google Scholar]
- Adamson T. M., Boyd R. D., Hill J. R., Normand I. C., Reynolds E. O., Strang L. B. Effect of asphyxia due to umbilical cord occlusion in the foetal lamb on leakage of liquid from the circulation and on permeability of lung capillaries to albumin. J Physiol. 1970 Apr;207(2):493–505. doi: 10.1113/jphysiol.1970.sp009075. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Alebouyeh M., Remien A., Marget W. Incidence of disseminated intravascular coagulation in the course of septicemia in newborn infants. Z Kinderheilkd. 1971;109(4):326–332. doi: 10.1007/BF00438976. [DOI] [PubMed] [Google Scholar]
- Ceballos R. Aspiration of maternal blood in the etiology of massive pulmonary hemorrhage in the newborn infant. J Pediatr. 1968 Mar;72(3):390–393. doi: 10.1016/s0022-3476(68)80214-8. [DOI] [PubMed] [Google Scholar]
- Cole V. A., Normand I. C., Reynolds E. O., Rivers R. P. Pathogenesis of hemorrhagic pulmonary edema and massive pulmonary hemorrhage in the newborn. Pediatrics. 1973 Feb;51(2):175–187. [PubMed] [Google Scholar]
- Corrigan J. J., Jr, Ray W. L., May N. Changes in the blood coagulation system associated with septicemia. N Engl J Med. 1968 Oct 17;279(16):851–856. doi: 10.1056/NEJM196810172791603. [DOI] [PubMed] [Google Scholar]
- DOWNING S. E., TALNER N. S., GARDNER T. H. VENTRICULAR FUNCTION IN THE NEWBORN LAMB. Am J Physiol. 1965 May;208:931–937. doi: 10.1152/ajplegacy.1965.208.5.931. [DOI] [PubMed] [Google Scholar]
- LANDING B. H. Pulmonary lesions of newborn infants; a statistical study. Pediatrics. 1957 Feb;19(2):217–223. [PubMed] [Google Scholar]
- LENDRUM A. C., FRASER D. S., SLIDDERS W., HENDERSON R. Studies on the character and staining of fibrin. J Clin Pathol. 1962 Sep;15:401–413. doi: 10.1136/jcp.15.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Xanthou M. Leucocyte blood picture in ill newborn babies. Arch Dis Child. 1972 Oct;47(255):741–746. doi: 10.1136/adc.47.255.741. [DOI] [PMC free article] [PubMed] [Google Scholar]