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. 1976 Mar 6;114(5):417–421.

Serum ferritin and the iron status of Canadians.

L S Valberg, J Sorbie, J Ludwig, O Pelletier
PMCID: PMC1956860  PMID: 1253085

Abstract

Serum ferritin concentration was determined in 1105 Canadians aged 1 to 90 years. Geometric mean values (ng/ml) were as follows: children 1 to 4 years old, 12; children 5 to 9 years old, 15; adolescent girls, 17; adolescent boys, 18; women 20 to 39 years, 23; women 65 years and older, 52; men 20 to 39 years, 93; and men 40 and older, 92. Ranges were side in all age groups, reflecting variations in size of body iron stores. From analysis of the ferritin values it is highly probably that iron stores were greatly reduced in approximately 25% of children, 30% of adolescents, 30% of menstruating women, 60% of pregnant women and 3% of men. Iron-deficiency anemia was noted in only 2% of subjects. If "normality" requires more than small amounts of storage iron to meet physiologic demands, the study results suggest a high probability of iron deficiency in 60% of the pregnant women and in 19% of the other subjects; but if normality is defined as maintenance of adequate iron stores for erythropoiesis, the prevalence of iron deficiency was zero in the pregnant women and 2% in the other subjects.

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Selected References

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  1. Addison G. M., Beamish M. R., Hales C. N., Hodgkins M., Jacobs A., Llewellin P. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J Clin Pathol. 1972 Apr;25(4):326–329. doi: 10.1136/jcp.25.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cook J. D., Lipschitz D. A., Miles L. E., Finch C. A. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr. 1974 Jul;27(7):681–687. doi: 10.1093/ajcn/27.7.681. [DOI] [PubMed] [Google Scholar]
  3. Crosby W. H. Serum ferritin and iron enrichment. N Engl J Med. 1974 Jun 20;290(25):1435–1436. doi: 10.1056/NEJM197406202902511. [DOI] [PubMed] [Google Scholar]
  4. Darby W. J. The case for the proposed increase in iron enrichment of flour and wheat products. Nutr Rev. 1972 Apr;30(4):98–102. doi: 10.1111/j.1753-4887.1972.tb04001.x. [DOI] [PubMed] [Google Scholar]
  5. De Leeuw N. K., Lowenstein L., Hsieh Y. S. Iron deficiency and hydremia in normal pregnancy. Medicine (Baltimore) 1966 Jul;45(4):291–315. doi: 10.1097/00005792-196607000-00002. [DOI] [PubMed] [Google Scholar]
  6. Finch C. A., Monsen E. R. Iron nutrition and the fortification of food with iron. JAMA. 1972 Mar 13;219(11):1462–1465. [PubMed] [Google Scholar]
  7. Finch C. A. Want amid plenty. Am J Clin Nutr. 1968 Oct;21(10):1138–1138. doi: 10.1093/ajcn/21.10.1138. [DOI] [PubMed] [Google Scholar]
  8. HAWKINS W. W., LEONARD V. G., SPECK E. The total body hemoglobin in children and its relation to caloric and iron requirements. Metabolism. 1956 Jan;5(1):70–78. [PubMed] [Google Scholar]
  9. Höglund S., Ehn L., Liedén G. Studies in iron absorption. VII. Iron deficiency in young men. Acta Haematol. 1970;44(4):193–199. doi: 10.1159/000208680. [DOI] [PubMed] [Google Scholar]
  10. Jacobs A., Miller F., Worwood M., Beamish M. R., Wardrop C. A. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. doi: 10.1136/bmj.4.5834.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jacobs A., Worwood M. Ferritin in serum. Clinical and biochemical implications. N Engl J Med. 1975 May 1;292(18):951–956. doi: 10.1056/NEJM197505012921805. [DOI] [PubMed] [Google Scholar]
  12. Kripke S. S., Sanders E. Prevalence of iron-deficiency anemia among infants and young children seen at rural amburatory clinics. Am J Clin Nutr. 1970 Jun;23(6):716–724. doi: 10.1093/ajcn/23.6.716. [DOI] [PubMed] [Google Scholar]
  13. Lipschitz D. A., Cook J. D., Finch C. A. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974 May 30;290(22):1213–1216. doi: 10.1056/NEJM197405302902201. [DOI] [PubMed] [Google Scholar]
  14. McFarlane D. B., Pinkerton P. H., Dagg J. H., Goldberg A. Incidence of iron deficiency, with and without anaemia, in women in general practice. Br J Haematol. 1967 Sep;13(5):790–796. doi: 10.1111/j.1365-2141.1967.tb08846.x. [DOI] [PubMed] [Google Scholar]
  15. Miles L. E., Lipschitz D. A., Bieber C. P., Cook J. D. Measurement of serum ferritin by a 2-site immunoradiometric assay. Anal Biochem. 1974 Sep;61(1):209–224. doi: 10.1016/0003-2697(74)90347-9. [DOI] [PubMed] [Google Scholar]
  16. Milne H., Beaton G. H., Latchford L. M., Vaughan M., Moss G. W. Hemoglobin levels and iron intakes of infants attending selected child health centres in the city of Toronto. Can Med Assoc J. 1971 Aug 7;105(3):279–282. [PMC free article] [PubMed] [Google Scholar]
  17. Monsen E. R., Kuhn I. N., Finch C. A. Iron status of menstruating women. Am J Clin Nutr. 1967 Aug;20(8):842–849. doi: 10.1093/ajcn/20.8.842. [DOI] [PubMed] [Google Scholar]
  18. Owen G. M., Lubin A. H., Garry P. J. Preschool children in the United States: who has iron deficiency? J Pediatr. 1971 Oct;79(4):563–568. doi: 10.1016/s0022-3476(71)80301-3. [DOI] [PubMed] [Google Scholar]
  19. Scott D. E., Pritchard J. A. Iron deficiency in healthy young college women. JAMA. 1967 Mar 20;199(12):897–900. [PubMed] [Google Scholar]
  20. Siimes M. A., Addiego J. E., Jr, Dallman P. R. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood. 1974 Apr;43(4):581–590. [PubMed] [Google Scholar]
  21. Swiss L. D., Beaton G. H. A prediction of the effects of iron fortification. Am J Clin Nutr. 1974 Apr;27(4):373–379. doi: 10.1093/ajcn/27.4.373. [DOI] [PubMed] [Google Scholar]
  22. Walters G. O., Miller F. M., Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol. 1973 Oct;26(10):770–772. doi: 10.1136/jcp.26.10.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Walters G. O., Thompson W., Jacobs A., Wood C. S. Letter: Iron stores and iron absorption. Lancet. 1973 Nov 24;2(7839):1216–1216. doi: 10.1016/s0140-6736(73)92994-2. [DOI] [PubMed] [Google Scholar]
  24. Weatherburn M. W., Stewart B. J., Logan J. E., Walker C. B., Allen R. H. A survey of hemoglobin values in Canada. Can Med Assoc J. 1970 Mar 14;102(5):493–498. [PMC free article] [PubMed] [Google Scholar]

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