Abstract
Anti-D (anti-Rho) in the blood of two Rh-negative pregnant women was believed to be due to active immunization. In the first case, however, antibodies were no longer detectable 2 weeks later. In the second case they disappeared by the end of 31 weeks. It was discovered that both women had been given immune globulin (human) because of exposure to rubella. The globulin given to the first woman probably contained about 0.1 mug of anti-D per ml; that given to the second probably contained about 0.6 mug of anti-D per ml. Both babies were O Rh-positive. Both women were given Rh immune globulin after delivery. Both have completed a further pregnancy and no anti-D has been found on many tests. In tests carried out in 1971 all samples of immune globulin (human) examined contained anti-D, but usually in inconsequential trace amounts.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chown B., Bowman J. M., Pollock J., Lowen B., Pettett A. The effect of anti-D IgG on D-positive recipients. Can Med Assoc J. 1970 May 30;102(11):1161–1164. [PMC free article] [PubMed] [Google Scholar]
- Lang G. E., Veldhuis B. Immune serum globulin--a cause for anti-Rh (D) passive sensitization. Am J Clin Pathol. 1973 Aug;60(2):205–207. doi: 10.1093/ajcp/60.2.205. [DOI] [PubMed] [Google Scholar]
- Oberman H. A., Beck M. L. Red blood cell sensitization due to unexpected Rh antibodies in immune serum globulin. Transfusion. 1971 Nov-Dec;11(6):382–384. doi: 10.1111/j.1537-2995.1971.tb04433.x. [DOI] [PubMed] [Google Scholar]