Correction for Eswaramoorthy et al., Mechanism of action of a flavin-containing monooxygenase

BIOCHEMISTRY. For the article “Mechanism of action of a flavin-containing monooxygenase,” by Subramaniam Eswaramoorthy, Jeffrey B. Bonanno, Stephen K. Burley, and Subramanyam Swaminathan, which appeared in issue 26, June 27, 2006, of Proc Natl Acad Sci USA (103:9832–9837; first published June 15, 2006; 10.1073/pnas.0602398103), the authors note the following: “A reader of the published article pointed out that the mechanism of Fig. 4 showing hydride transfer from the C2 position is not compatible with known NADH chemistry, which entails hydride transfer to and from C4. Our explanation and Fig. 4 were based on our crystal structure, in which C2 of NADH was close to N5 of the isoalloxazine moiety of FMN. Accordingly, we suggest that the crystal structure possibly represents a transient stage before or after the proton transfer. The remainder of the article is not affected by this change.”