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. 1967 Mar;50(3):485–521.

An electron microscopic study of leukocyte emigration and vascular permeability in tuberculin sensitivity.

J Wiener, R G Lattes, D Spiro
PMCID: PMC1965278  PMID: 6018675

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENNETT H. S., LUFT J. H., HAMPTON J. C. Morphological classifications of vertebrate blood capillaries. Am J Physiol. 1959 Feb;196(2):381–390. doi: 10.1152/ajplegacy.1959.196.2.381. [DOI] [PubMed] [Google Scholar]
  2. BURKE J. S., URIUHARA T., MACMORINE D. R., MOVAT H. Z. A PERMEABILITY FACTOR RELEASED FROM PHAGOCYTOSING PMN-LEUKOCYTES AND ITS INHIBITION BY PROTEASE INHIBITORS. Life Sci. 1964 Dec;3:1505–1512. doi: 10.1016/0024-3205(64)90097-9. [DOI] [PubMed] [Google Scholar]
  3. COHN Z. A., HIRSCH J. G. The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes. J Exp Med. 1960 Dec 1;112:983–1004. doi: 10.1084/jem.112.6.983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COTRAN R. S., MAJNO G. THE DELAYED AND PROLONGED VASCULAR LEAKAGE IN INFLAMMATION. I. TOPOGRAPHY OF THE LEAKING VESSELS AFTER THERMAL INJURY. Am J Pathol. 1964 Aug;45:261–281. [PMC free article] [PubMed] [Google Scholar]
  5. COTRAN R. S. THE DELAYED AND PROLONGED VASCULAR LEAKAGE IN INFLAMMATION. II. AN ELECTRON MICROSCOPIC STUDY OF THE VASCULAR RESPONSE AFTER THERMAL INJURY. Am J Pathol. 1965 Apr;46:589–620. [PMC free article] [PubMed] [Google Scholar]
  6. Coe J. E., Feldman J. D., Lee S. Immunologic competence of thoracic duct cells. I. Delayed hypersensitivity. J Exp Med. 1966 Feb 1;123(2):267–281. doi: 10.1084/jem.123.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dienes L., Mallory T. B. Histological Studies of Hypersensitive Reactions. Am J Pathol. 1932 Nov;8(6):689–710.3. [PMC free article] [PubMed] [Google Scholar]
  8. FAWCETT D. W. Physiologically significant specializations of the cell surface. Circulation. 1962 Nov;26:1105–1132. doi: 10.1161/01.cir.26.5.1105. [DOI] [PubMed] [Google Scholar]
  9. FLAX M. H., CAULFIELD J. B. CELLULAR AND VASCULAR COMPONENTS OF ALLERGIC CONTACT DERMATITIS. Am J Pathol. 1963 Dec;43:1031–1053. [PMC free article] [PubMed] [Google Scholar]
  10. FLOREY H. W., GRANT L. H. Leucocyte migration from small blood vessels stimulated with ultraviolet light: an electron-microscope study. J Pathol Bacteriol. 1961 Jul;82:13–17. doi: 10.1002/path.1700820103. [DOI] [PubMed] [Google Scholar]
  11. FRENCH J. E., FLOREY H. W., MORRIS B. The absorption of particles by the lymphatics of the diaphragm. Q J Exp Physiol Cogn Med Sci. 1960 Jan;45:88–103. doi: 10.1113/expphysiol.1960.sp001448. [DOI] [PubMed] [Google Scholar]
  12. GELL P. G. H., HINDE I. T. The histology of the tuberculin reaction and its modification by cortisone. Br J Exp Pathol. 1951 Dec;32(6):516–529. [PMC free article] [PubMed] [Google Scholar]
  13. Golub E. S., Spitznagel J. K. The role of lysosomes in hypersensitivity reactions: tissue damage by polymorphonuclear neutrophil lysosomes. J Immunol. 1965 Dec;95(6):1060–1066. [PubMed] [Google Scholar]
  14. HALPERN B. N. INHIBITION OF THE LOCAL HEMORRHAGIC SHWARTZMAN REACTION BY A POLYPEPTIDE POSSESSING POTENT ANTIPROTEASE ACTIVITY. Proc Soc Exp Biol Med. 1964 Feb;115:273–276. doi: 10.3181/00379727-115-28889. [DOI] [PubMed] [Google Scholar]
  15. HURLEY J. V. ACUTE INFLAMMATION: THE EFFECT OF CONCURRENT LEUCOCYTIC EMIGRATION AND INCREASED PERMEABILITY ON PARTICLE RETENTION BY THE VASCULAR WALL. Br J Exp Pathol. 1964 Dec;45:627–633. [PMC free article] [PubMed] [Google Scholar]
  16. HURLEY J. V. An electron microscopic study of leucocytic emigration and vascular permeability in rat skin. Aust J Exp Biol Med Sci. 1963 Apr;41:171–186. doi: 10.1038/icb.1963.17. [DOI] [PubMed] [Google Scholar]
  17. HURLEY J. V., SPECTOR W. G. A TOPOGRAPHICAL STUDY OF INCREASED VASCULAR PERMEABILITY IN ACUTE TURPENTINE-INDUCED PLEURISY. J Pathol Bacteriol. 1965 Jan;89:245–254. [PubMed] [Google Scholar]
  18. HURLEY J. V., XEROS N. Electron microscopic observations on the emigration of leucocytes. Aust J Exp Biol Med Sci. 1961 Dec;39:609–623. doi: 10.1038/icb.1961.60. [DOI] [PubMed] [Google Scholar]
  19. Ham K. N., Hurley J. V. Acute inflammation: an electron-microscope study of turpentine-induced pleurisy in the rat. J Pathol Bacteriol. 1965 Oct;90(2):365–377. doi: 10.1002/path.1700900202. [DOI] [PubMed] [Google Scholar]
  20. INDERBITZIN T. The effect of acute and delayed cutaneous allergic reactions on the amount of histamine in the skin. Int Arch Allergy Appl Immunol. 1955;7(3):140–148. doi: 10.1159/000228221. [DOI] [PubMed] [Google Scholar]
  21. JANOFF A., ZWEIFACH B. W. PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES. J Exp Med. 1964 Nov 1;120:747–764. doi: 10.1084/jem.120.5.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Janoff A., Schaefer S., Scherer J., Bean M. A. Mediators of inflammation in leukocyte lysosomes. II. Mechanism of action of lysosomal cationic protein upon vascular permeability in the rat. J Exp Med. 1965 Nov 1;122(5):841–851. doi: 10.1084/jem.122.5.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. KARRER H. E. Electron microscopic study of the phagocytosis process in lung. J Biophys Biochem Cytol. 1960 Apr;7:357–366. doi: 10.1083/jcb.7.2.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MAJNO G., PALADE G. E. Studies on inflammation. 1. The effect of histamine and serotonin on vascular permeability: an electron microscopic study. J Biophys Biochem Cytol. 1961 Dec;11:571–605. doi: 10.1083/jcb.11.3.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. MARCHESI V. T., FLOREY H. W. Electron micrographic observations on the emigration of leucocytes. Q J Exp Physiol Cogn Med Sci. 1960 Oct;45:343–348. doi: 10.1113/expphysiol.1960.sp001489. [DOI] [PubMed] [Google Scholar]
  26. MARCHESI V. T., GOWANS J. L. THE MIGRATION OF LYMPHOCYTES THROUGH THE ENDOTHELIUM OF VENULES IN LYMPH NODES: AN ELECTRON MICROSCOPE STUDY. Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:283–290. doi: 10.1098/rspb.1964.0002. [DOI] [PubMed] [Google Scholar]
  27. MAYASHI H., MIYOSHI H., NITTA R., UDAKA K. Proteolytic mechanism in recurrence of Arthus-type inflammation by thiol compounds. Br J Exp Pathol. 1962 Oct;43:564–573. [PMC free article] [PubMed] [Google Scholar]
  28. METAXAS M. N., METAXAS-BUEHLER M. Studies on the cellular transfer of tuberculin sensitivity in the guinea pig. J Immunol. 1955 Nov;75(5):333–347. [PubMed] [Google Scholar]
  29. MOVAT H. Z., FERNANDO N. V. ACUTE INFLAMMATION. THE EARLIEST FINE STRUCTURAL CHANGES AT THE BLOOD-TISSUE BARRIER. Lab Invest. 1963 Sep;12:895–910. [PubMed] [Google Scholar]
  30. PAGE A. R. STUDIES ON THE LYMPHOCYTE RESPONSE TO INFLAMMATION. Ann N Y Acad Sci. 1964 Aug 27;116:950–963. doi: 10.1111/j.1749-6632.1964.tb52561.x. [DOI] [PubMed] [Google Scholar]
  31. PALADE G. E. Blood capillaries of the heart and other organs. Circulation. 1961 Aug;24:368–388. doi: 10.1161/01.cir.24.2.368. [DOI] [PubMed] [Google Scholar]
  32. PAZ R. A., SPECTOR W. G. The mononuclear-cell response to injury. J Pathol Bacteriol. 1962 Jul;84:85–103. doi: 10.1002/path.1700840111. [DOI] [PubMed] [Google Scholar]
  33. REBUCK J. W., CROWLEY J. H. A method of studying leukocytic functions in vivo. Ann N Y Acad Sci. 1955 Mar 24;59(5):757–805. doi: 10.1111/j.1749-6632.1955.tb45983.x. [DOI] [PubMed] [Google Scholar]
  34. SKOG E. Experimental studies on hypersensitivity to 2, 4-dinitrochlorobenzene and tuberculin in animals. I. Passive transfer of hypersensitivity to 2, 4-dinitrochlorobenzene. Acta Derm Venereol. 1955;35(2):93–106. [PubMed] [Google Scholar]
  35. THOMAS L. POSSIBLE ROLE OF LEUCOCYTE GRANULES IN THE SHWARTZMAN AND ARTHUS REACTIONS. Proc Soc Exp Biol Med. 1964 Jan;115:235–240. doi: 10.3181/00379727-115-28879. [DOI] [PubMed] [Google Scholar]
  36. WAKSMAN B. H., ARBOUYS S., ARNASON B. G. The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type. J Exp Med. 1961 Dec 1;114:997–1022. doi: 10.1084/jem.114.6.997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. WAKSMAN B. H. The distribution of experimental auto-allergic lesions. Its relation to the distribution of small veins. Am J Pathol. 1960 Dec;37:673–693. [PMC free article] [PubMed] [Google Scholar]
  38. WALTERS M. N., WILLOUGHBY D. A. THE EFFECT OF TISSUE EXTRACTS ON VASCULAR PERMEABILITY AND LEUCOCYTE EMIGRATION. J Pathol Bacteriol. 1965 Jan;89:255–262. doi: 10.1002/path.1700890126. [DOI] [PubMed] [Google Scholar]
  39. WEISSMANN G., THOMAS L. Studies on lysosomes. II. The effect of cortisone on the release of acid hydrolases from a large granule fraction of rabbit liver induced by an excess of vitamin A. J Clin Invest. 1963 May;42:661–669. doi: 10.1172/JCI104757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. WESSLEN T. Passive transfer of tuberculin hypersensitivity by viable lymphocytes from the thoracic duct. Acta Tuberc Scand. 1952;26(1-2):38–53. [PubMed] [Google Scholar]
  41. WIENER J., SPIRO D. Electron microscope studies in experimental thrombosis. Exp Mol Pathol. 1962 Dec;1:554–572. doi: 10.1016/0014-4800(62)90042-4. [DOI] [PubMed] [Google Scholar]
  42. WIENER J., SPIRO D., MARGARETTEN W. AN ELECTRON MICROSCOPIC STUDY OF RETICULOENDOTHELIAL SYSTEM BLOCKADE. Am J Pathol. 1964 Nov;45:783–803. [PMC free article] [PubMed] [Google Scholar]
  43. WILHELM R. E., FISHER J. P., COOKE R. A. Experimental depletion of mononuclear cells for the purpose of investigating reactions of the allergic contact type. J Allergy. 1958 Nov-Dec;29(6):493–501. doi: 10.1016/0021-8707(58)90021-2. [DOI] [PubMed] [Google Scholar]
  44. WILLIAMSON J. R., GRISHAM J. W. Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas. Am J Pathol. 1961 Aug;39:239–256. [PMC free article] [PubMed] [Google Scholar]
  45. WILLOUGHBY D. A., BOUGHTON B., SCHILD H. O. A FACTOR CAPABLE OF INCREASING VASCULAR PERMEABILITY PRESENT IN LYMPH NODE CELLS. A POSSIBLE MEDIATOR OF THE DELAYED REACTION. Immunology. 1963 Sep;6:484–498. [PMC free article] [PubMed] [Google Scholar]
  46. WILLOUGHBY D. A., BOUGHTON B., SPECTOR W. G., SCHILD H. O. A vascular permeability factor extracted from normal and sensitized guinea-pig lymph node cells. Life Sci. 1962 Jul;1:347–352. doi: 10.1016/0024-3205(62)90131-5. [DOI] [PubMed] [Google Scholar]
  47. WILLOUGHBY D. A., SPECTOR W. G., BOUGHTON B. A LYMPH-NODE PERMEABILITY FACTOR IN THE TUBERCULIN REACTION. J Pathol Bacteriol. 1964 Apr;87:353–363. doi: 10.1002/path.1700870216. [DOI] [PubMed] [Google Scholar]
  48. WILLOUGHBY D. A., SPECTOR W. G. THE PRODUCTION OF EOSINOPHILIC DEPOSITS RESEMBLING FIBRINOID BY INJECTIONS OF LYMPH-NODE EXTRACTS. J Pathol Bacteriol. 1964 Oct;88:557–562. doi: 10.1002/path.1700880220. [DOI] [PubMed] [Google Scholar]
  49. Wiener J., Spiro D., Zunker H. O. A cellular study of tuberculin sensitivity. Am J Pathol. 1965 Nov;47(5):723–763. [PMC free article] [PubMed] [Google Scholar]

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