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. 1993 Mar;67(3):413–423. doi: 10.1038/bjc.1993.81

Stem cell origins of leukaemia and curability.

M F Greaves 1
PMCID: PMC1968264  PMID: 8439493

Abstract

It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.

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Selected References

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