Abstract
In further analyses of a cohort of 39,718 United Kingdom Atomic Energy Authority employees after 7 more years follow-up, cancer mortality, based on 1,506 deaths in 1946-86, was 20% below the national average. Prostatic cancer mortality showed a statistically significant association with external radiation exposure, largely confined to men who were also monitored for internal contamination by radionuclides other than plutonium. Prostatic cancer mortality was highest in radiation workers at Winfrith. In women monitored for radiation exposure, mortality from cancer of the uterus (including the cervix uteri) was increased relative to other employees, and, showed a statistically significant association with external radiation exposure. While there were some other statistically significant results, as would be expected by chance alone when multiple comparisons are made, there were no other cancer sites with consistently exceptional findings. Point estimates for risk associated with increasing exposure to radiation suggest a decrease of four deaths per 10(4) person-years per Sv for leukaemia and an increase of 20 deaths for all cancers except leukaemia, but confidence intervals indicate that a wide range of values are compatible with the data. Cancer morbidity based on 1,699 registrations in 1971-84 was 12% below the national average. Findings from site-specific analyses largely replicated those of the mortality analyses.
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- Beral V., Fraser P., Carpenter L., Booth M., Brown A., Rose G. Mortality of employees of the Atomic Weapons Establishment, 1951-82. BMJ. 1988 Sep 24;297(6651):757–770. doi: 10.1136/bmj.297.6651.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beral V., Inskip H., Fraser P., Booth M., Coleman D., Rose G. Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-1979. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):440–447. doi: 10.1136/bmj.291.6493.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carpenter L., Beral V., Fraser P., Booth M. Health related selection and death rates in the United Kingdom Atomic Energy Authority workforce. Br J Ind Med. 1990 Apr;47(4):248–258. doi: 10.1136/oem.47.4.248. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fraser P., Booth M., Beral V., Inskip H., Firsht S., Speak S. Collection and validation of data in the United Kingdom Atomic Energy Authority mortality study. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):435–439. doi: 10.1136/bmj.291.6493.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilbert E. S., Fry S. A., Wiggs L. D., Voelz G. L., Cragle D. L., Petersen G. R. Analyses of combined mortality data on workers at the Hanford Site, Oak Ridge National Laboratory, and Rocky Flats Nuclear Weapons Plant. Radiat Res. 1989 Oct;120(1):19–35. [PubMed] [Google Scholar]
- Gilbert E. S. Issues in analysing the effects of occupational exposure to low levels of radiation. Stat Med. 1989 Feb;8(2):173–187. doi: 10.1002/sim.4780080205. [DOI] [PubMed] [Google Scholar]
- Inskip H., Beral V., Fraser P., Booth M., Coleman D., Brown A. Further assessment of the effects of occupational radiation exposure in the United Kingdom Atomic Energy Authority mortality study. Br J Ind Med. 1987 Mar;44(3):149–160. doi: 10.1136/oem.44.3.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kendall G. M., Muirhead C. R., MacGibbon B. H., O'Hagan J. A., Conquest A. J., Goodill A. A., Butland B. K., Fell T. P., Jackson D. A., Webb M. A. Mortality and occupational exposure to radiation: first analysis of the National Registry for Radiation Workers. BMJ. 1992 Jan 25;304(6821):220–225. doi: 10.1136/bmj.304.6821.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith P. G., Douglas A. J. Mortality of workers at the Sellafield plant of British Nuclear Fuels. Br Med J (Clin Res Ed) 1986 Oct 4;293(6551):845–854. doi: 10.1136/bmj.293.6551.845. [DOI] [PMC free article] [PubMed] [Google Scholar]