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. 1993 Jul;68(1):125–129. doi: 10.1038/bjc.1993.299

Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.

A Katagiri 1, Y Tomita 1, T Nishiyama 1, M Kimura 1, S Sato 1
PMCID: PMC1968284  PMID: 8100442

Abstract

P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GSTP1-1. Western blot analysis demonstrated lower amount of GSTP1-1 in seminoma than in teratoma. These results suggest that Pgp and GSTP1-1 might contribute to drug resistance in testis cancers.

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Selected References

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