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. 1993 Jul;68(1):10–12. doi: 10.1038/bjc.1993.278

Effect of cryosurgery on liver blood flow.

N J Brown 1, P Bayjoo 1, M W Reed 1
PMCID: PMC1968305  PMID: 8318398

Abstract

The effect of cryosurgery on normal liver and liver tumour was investigated using 60 adult male rats. Animals were divided into four groups Group A implanted tumour/cryosurgery (n = 19), Group B normal liver/cryosurgery (n = 17), Group C normal liver/sham cryosurgery (n = 10) and Group D implanted tumour/sham cryosurgery (n = 14). At laparotomy animals were injected into the left lateral lobe of the liver with 10(5) HSN fibrosarcoma cells or vehicle. Two weeks after implantation red cell flux was recorded in all animals, the appropriate groups treated with cryosurgery and after thawing red cell flux was monitored over the tumour and at the edge of the cryolesion and over the corresponding normal area in controls. In certain animals red cell flux was measured at hourly intervals for 8 h, and in further groups at 24 h and at 2 weeks after cryosurgery. Results demonstrated that cryosurgery significantly reduced (P < 0.01) red cell flux in both normal and tumour liver, immediately after treatment. Red cell flux remained significantly reduced (P < 0.005) at 8 h after treatment but by 24 h had returned to preoperative levels which was maintained at 2 weeks. The results suggest that microcirculatory shutdown may be a contributing factor to the tumour necrosis occurring after cryosurgery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Charnley R. M., Doran J., Morris D. L. Cryotherapy for liver metastases: a new approach. Br J Surg. 1989 Oct;76(10):1040–1041. doi: 10.1002/bjs.1800761018. [DOI] [PubMed] [Google Scholar]
  2. Currie G. A., Gage J. O. Influence of tumour growth on the evolution of cytotoxic lymphoid cells in rats bearing a spontaneously metastasizing syngeneic fibrosarcoma. Br J Cancer. 1973 Aug;28(2):136–146. doi: 10.1038/bjc.1973.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gage A. A., Guest K., Montes M., Caruana J. A., Whalen D. A., Jr Effect of varying freezing and thawing rates in experimental cryosurgery. Cryobiology. 1985 Apr;22(2):175–182. doi: 10.1016/0011-2240(85)90172-5. [DOI] [PubMed] [Google Scholar]
  4. Gana T. J., Huhlewych R., Koo J. Focal gastric mucosal blood flow by laser-Doppler and hydrogen gas clearance: a comparative study. J Surg Res. 1987 Oct;43(4):337–343. doi: 10.1016/0022-4804(87)90090-4. [DOI] [PubMed] [Google Scholar]
  5. Horwitz N. H., Gokalp H., Randall J. In situ freezing of the common carotid artery and sagittal sinus of the dog. Cryobiology. 1966 Jan-Feb;2(4):223–228. doi: 10.1016/s0011-2240(66)80172-4. [DOI] [PubMed] [Google Scholar]
  6. Jacob G., Kurzer M. N., Fuller B. J. An assessment of tumor cell viability after in vitro freezing. Cryobiology. 1985 Oct;22(5):417–426. doi: 10.1016/0011-2240(85)90152-x. [DOI] [PubMed] [Google Scholar]
  7. McIntosh G. S., Hobbs K. E., O'Reilly A. P. In situ freezing of the pancreas and portal vein in the pig. Cryobiology. 1985 Apr;22(2):183–190. doi: 10.1016/0011-2240(85)90173-7. [DOI] [PubMed] [Google Scholar]
  8. Neel H. B., 3rd, Ketcham A. S., Hammond W. G. Requisites for successful cryogenic surgery of cancer. Arch Surg. 1971 Jan;102(1):45–48. doi: 10.1001/archsurg.1971.01350010047012. [DOI] [PubMed] [Google Scholar]
  9. Smits G. J., Roman R. J., Lombard J. H. Evaluation of laser-Doppler flowmetry as a measure of tissue blood flow. J Appl Physiol (1985) 1986 Aug;61(2):666–672. doi: 10.1152/jappl.1986.61.2.666. [DOI] [PubMed] [Google Scholar]
  10. Whittaker D. K. Mechanisms of tissue destruction following cryosurgery. Ann R Coll Surg Engl. 1984 Sep;66(5):313–318. [PMC free article] [PubMed] [Google Scholar]

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