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. 1993 Jul;68(1):191–194. doi: 10.1038/bjc.1993.312

Chemotherapeutic treatment of recurrent and/or metastatic nasopharyngeal carcinoma: a retrospective analysis of 40 cases.

V Gebbia 1, G Zerillo 1, G Restivo 1, R Speciale 1, G Cupido 1, P Lo Bue 1, F Ingria 1, S Gallina 1, G Spatafora 1, A Testa 1, et al.
PMCID: PMC1968311  PMID: 7686391

Abstract

Authors carried out a review of 40 cases of recurrent and/or metastatic nasopharyngeal carcinoma (NPC) treated with cisplatin-based chemotherapy at the Division of Othorhinolaryngology and the Service of Chemotherapy of the University of Palermo between July 1984 and July 1992. All patients were treated with regimens comprising high dose cisplatin (80-100 mg m-2). Histologically there were 29 squamous cell and 11 undifferentiated NPC. Thirty-nine patients were evaluable for response and toxicity. The overall response rate was 64%, with a 20.5% complete response rate and a 43.5% partial response rate. The mean duration of complete responses was 10.2+months, while that of partial responses was 8.6+months. The mean survival of the whole group was 11.4+months, with four patients alive after 2 years of follow-up. No statistically significant difference in response rate and survival was found between patients with metastatic disease and those with locoregional recurrency, and between patients with squamous cell NPC and those with undifferentiated histology. The employed regimens have been generally well tolerated. These data confirm that NPC is a neoplasm highly responsive to chemotherapy. However, duration of objective response and survival are still largely unsatisfactory.

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Selected References

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  1. Al-Sarraf M. Head and neck cancer: chemotherapy concepts. Semin Oncol. 1988 Feb;15(1):70–85. [PubMed] [Google Scholar]
  2. Amrein P. C., Weitzman S. A. Treatment of squamous-cell carcinoma of the head and neck with cisplatin and 5-fluorouracil. J Clin Oncol. 1985 Dec;3(12):1632–1639. doi: 10.1200/JCO.1985.3.12.1632. [DOI] [PubMed] [Google Scholar]
  3. Bachouchi M., Cvitkovic E., Azli N., Gasmi J., Cortes-Funes H., Boussen H., Rahal M., Kalifa C., Schwaab G., Eschwege F. High complete response in advanced nasopharyngeal carcinoma with bleomycin, epirubicin, and cisplatin before radiotherapy. J Natl Cancer Inst. 1990 Apr 4;82(7):616–620. doi: 10.1093/jnci/82.7.616. [DOI] [PubMed] [Google Scholar]
  4. Bedwinek J. M., Perez C. A., Keys D. J. Analysis of failures after definitive irradiation for epidermoid carcinoma of the nasopharynx. Cancer. 1980 Jun 1;45(11):2725–2729. doi: 10.1002/1097-0142(19800601)45:11<2725::aid-cncr2820451105>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  5. Choksi A. J., Hong W. K., Dimery I. W., James P., Guillamondegui O. M., Byers R. M. Continuous cisplatin (24-hour) and 5-fluorouracil (120-hour) infusion in recurrent head and neck squamous cell carcinoma. Cancer. 1988 Mar 1;61(5):909–912. doi: 10.1002/1097-0142(19880301)61:5<909::aid-cncr2820610509>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  6. Choo R., Tannock I. Chemotherapy for recurrent or metastatic carcinoma of the nasopharynx. A review of the Princess Margaret Hospital experience. Cancer. 1991 Nov 15;68(10):2120–2124. doi: 10.1002/1097-0142(19911115)68:10<2120::aid-cncr2820681005>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  7. Clark J. R., Norris C. M., Jr, Dreyfuss A. I., Fallon B. G., Balogh K., Anderson R. F., Jr, Chaffey J. T., Andersen J. W., Miller D. Nasopharyngeal carcinoma: the Dana-Farber Cancer Institute experience with 24 patients treated with induction chemotherapy and radiotherapy. Ann Otol Rhinol Laryngol. 1987 Sep-Oct;96(5):608–614. doi: 10.1177/000348948709600525. [DOI] [PubMed] [Google Scholar]
  8. Fedder M., Gonzalez M. F. Nasopharyngeal carcinoma. Brief review. Am J Med. 1985 Sep;79(3):365–369. doi: 10.1016/0002-9343(85)90315-8. [DOI] [PubMed] [Google Scholar]
  9. Fee W. E., Jr Nasopharyngeal carcinoma. Curr Opin Oncol. 1990 Jun;2(3):585–588. [PubMed] [Google Scholar]
  10. Gebbia V., Russo A., Gebbia N., Rausa L., Ingria F., Spatafora G., Zerillo G., Cimino A., Pastorello T., Ferrara P. High-dose folinic acid and 5-fluorouracil plus cisplatin on a weekly schedule in the treatment of advanced cancer of the head and neck. J Cancer Res Clin Oncol. 1992;118(6):458–462. doi: 10.1007/BF01629430. [DOI] [PubMed] [Google Scholar]
  11. Gebbia V., Zerillo G., Gebbia N., Agostara B., Callari A., Rausa L. Chemotherapy in head and neck cancer (I): Management of recurrent or metastatic disease. J Chemother. 1992 Aug;4(4):244–259. doi: 10.1080/1120009x.1992.11739173. [DOI] [PubMed] [Google Scholar]
  12. Hill B. T., Price L. A., MacRae K. Importance of primary site in assessing chemotherapy response and 7-year survival data in advanced squamous-cell carcinomas of the head and neck treated with initial combination chemotherapy without cisplatin. J Clin Oncol. 1986 Sep;4(9):1340–1347. doi: 10.1200/JCO.1986.4.9.1340. [DOI] [PubMed] [Google Scholar]
  13. Huang S. C. Nasopharyngeal cancer: a review of 1605 patients treated radically with cobalt 60. Int J Radiat Oncol Biol Phys. 1980 Apr;6(4):401–407. [PubMed] [Google Scholar]
  14. Huang S., Chu G. Nasopharyngeal cancer: study II. Int J Radiat Oncol Biol Phys. 1981 Jun;7(6):713–716. doi: 10.1016/0360-3016(81)90462-4. [DOI] [PubMed] [Google Scholar]
  15. Merino O. R., Lindberg R. D., Fletcher G. H. An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer. 1977 Jul;40(1):145–151. doi: 10.1002/1097-0142(197707)40:1<145::aid-cncr2820400124>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  16. Merlano M., Grimaldi A., Brunetti I., Modenesi M., Scala M., Margarino G., Scasso F., Santelli A., Castiglia G., Pallestrini E. Simultaneous cisplatin and 5-fluorouracil as second-line treatment of head and neck cancer. Cancer Treat Rep. 1987 May;71(5):485–488. [PubMed] [Google Scholar]
  17. Palmeri S., Gebbia V., Russo A., Gebbia N., Oliveri D., Rausa L. Cis-diamminodichloroplatinum plus a 5-day continuous infusion of 5-fluorouracil in the treatment of locally recurrent and metastatic head and neck cancer patients. J Cancer Res Clin Oncol. 1989;115(6):579–582. doi: 10.1007/BF00391362. [DOI] [PubMed] [Google Scholar]
  18. Tannock I., Payne D., Cummings B., Hewitt K., Panzarella T. Sequential chemotherapy and radiation for nasopharyngeal cancer: absence of long-term benefit despite a high rate of tumor response to chemotherapy. J Clin Oncol. 1987 Apr;5(4):629–634. doi: 10.1200/JCO.1987.5.4.629. [DOI] [PubMed] [Google Scholar]
  19. Vikram B., Mishra U. B., Strong E. W., Manolatos S. Patterns of failure in carcinoma of the nasopharynx: I. Failure at the primary site. Int J Radiat Oncol Biol Phys. 1985 Aug;11(8):1455–1459. doi: 10.1016/0360-3016(85)90332-3. [DOI] [PubMed] [Google Scholar]
  20. Vikram B., Mishra U. B., Strong E. W., Manolatos S. Patterns of failure in carcinoma of the nasopharynx: failure at distant sites. Head Neck Surg. 1986 Mar-Apr;8(4):276–279. doi: 10.1002/hed.2890080407. [DOI] [PubMed] [Google Scholar]
  21. Yates J. W., Chalmer B., McKegney F. P. Evaluation of patients with advanced cancer using the Karnofsky performance status. Cancer. 1980 Apr 15;45(8):2220–2224. doi: 10.1002/1097-0142(19800415)45:8<2220::aid-cncr2820450835>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]

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