Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1993 Apr;67(4):783–786. doi: 10.1038/bjc.1993.142

Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.

C K Williams 1, S S Alexander 1, A Bodner 1, A Levine 1, C Saxinger 1, R C Gallo 1, W A Blattner 1
PMCID: PMC1968344  PMID: 8471436

Abstract

Sera from a small sample of adult blood donors, healthy school children and patients with lymphoma, leukaemia, non-haematologic cancer, congenital and inflammatory disorders from Ibadan, Nigeria were screened for HTLV-I antibody by an enzyme-linked immunoabsorbent assay and confirmed by investigational Western blot. Seventy-nine of 236 positively screened samples could not be tested for confirmation. Seropositive reactivity was observed in nine of 123 blood donors, and 3 of 46 healthy school children but banding patterns on Western blot were often sparse. Among non-Burkitt's non Hodgkin's lymphoma patients six of 30 were HTLV-I positive including four of four with clinical features of adult T-cell leukaemia (ATL). Other clinical conditions had a frequency of positivity indistinguishable from healthy donors. Western blot patterns ranged from strong with multiple bands, which were uncommon, to those with only p24 and p21 envelope positive which were frequent. Given the relative paucity of clinical ATL and the unusual Western blot patterns the true rate of HTLV-I infection may be lower than estimated. It is possible that a cross-reactive HTLV-I-like virus accounts for this pattern.

Full text

PDF
783

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartholomew C., Charles W., Saxinger C., Blattner W., Robert-Guroff M., Raju C., Ratan P., Ince W., Quamina D., Basdeo-Maharaj K. Racial and other characteristics of human T cell leukemia/lymphoma (HTLV-I) and AIDS (HTLV-III) in Trinidad. Br Med J (Clin Res Ed) 1985 Apr 27;290(6477):1243–1246. doi: 10.1136/bmj.290.6477.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Biggar R. J., Gigase P. L., Melbye M., Kestens L., Sarin P. S., Bodner A. J., Demedts P., Stevens W. J., Paluku L., Delacollette C. ELISA HTLV retrovirus antibody reactivity associated with malaria and immune complexes in healthy Africans. Lancet. 1985 Sep 7;2(8454):520–523. doi: 10.1016/s0140-6736(85)90461-1. [DOI] [PubMed] [Google Scholar]
  3. Blattner W. A., Gibbs W. N., Saxinger C., Robert-Guroff M., Clark J., Lofters W., Hanchard B., Campbell M., Gallo R. C. Human T-cell leukaemia/lymphoma virus-associated lymphoreticular neoplasia in Jamaica. Lancet. 1983 Jul 9;2(8341):61–64. doi: 10.1016/s0140-6736(83)90056-9. [DOI] [PubMed] [Google Scholar]
  4. Blayney D. W., Blattner W. A., Robert-Guroff M., Jaffe E. S., Fisher R. I., Bunn P. A., Jr, Patton M. G., Rarick H. R., Gallo R. C. The human T-cell leukemia-lymphoma virus in the southeastern United States. JAMA. 1983 Aug 26;250(8):1048–1052. [PubMed] [Google Scholar]
  5. Catovsky D., Greaves M. F., Rose M., Galton D. A., Goolden A. W., McCluskey D. R., White J. M., Lampert I., Bourikas G., Ireland R. Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet. 1982 Mar 20;1(8273):639–643. doi: 10.1016/s0140-6736(82)92200-0. [DOI] [PubMed] [Google Scholar]
  6. Centers for Disease Control (CDC) Licensure of screening tests for antibody to human T-lymphotropic virus type I. MMWR Morb Mortal Wkly Rep. 1988 Dec 9;37(48):736-40, 745-7. [PubMed] [Google Scholar]
  7. Delaporte E., Dupont A., Peeters M., Josse R., Merlin M., Schrijvers D., Hamono B., Bedjabaga L., Cheringou H., Boyer F. Epidemiology of HTLV-I in Gabon (Western Equatorial Africa). Int J Cancer. 1988 Nov 15;42(5):687–689. doi: 10.1002/ijc.2910420509. [DOI] [PubMed] [Google Scholar]
  8. Delaporte E., Monplaisir N., Louwagie J., Peeters M., Martin-Prével Y., Louis J. P., Trebucq A., Bedjabaga L., Ossari S., Honoré C. Prevalence of HTLV-I and HTLV-II infection in Gabon, Africa: comparison of the serological and PCR results. Int J Cancer. 1991 Sep 30;49(3):373–376. doi: 10.1002/ijc.2910490310. [DOI] [PubMed] [Google Scholar]
  9. Delaporte E., Peeters M., Simoni M., Piot P. HTLV-I infection in western equatorial Africa. Lancet. 1989 Nov 18;2(8673):1226–1226. doi: 10.1016/s0140-6736(89)91840-0. [DOI] [PubMed] [Google Scholar]
  10. Fleming A. F., Maharajan R., Abraham M., Kulkarni A. G., Bhusnurmath S. R., Okpara R. A., Williams E., Akinsete I., Schneider J., Bayer H. Antibodies to HTLV-I in Nigerian blood-donors, their relatives and patients with leukaemias, lymphomas and other diseases. Int J Cancer. 1986 Dec 15;38(6):809–813. doi: 10.1002/ijc.2910380605. [DOI] [PubMed] [Google Scholar]
  11. Gibbs W. N., Lofters W. S., Campbell M., Hanchard B., LaGrenade L., Cranston B., Hendriks J., Jaffe E. S., Saxinger C., Robert-Guroff M. Non-Hodgkin lymphoma in Jamaica and its relation to adult T-cell leukemia-lymphoma. Ann Intern Med. 1987 Mar;106(3):361–368. doi: 10.7326/0003-4819-106-3-361. [DOI] [PubMed] [Google Scholar]
  12. LaGrenade L., Hanchard B., Fletcher V., Cranston B., Blattner W. Infective dermatitis of Jamaican children: a marker for HTLV-I infection. Lancet. 1990 Dec 1;336(8727):1345–1347. doi: 10.1016/0140-6736(90)92896-p. [DOI] [PubMed] [Google Scholar]
  13. Lairmore M. D., Jacobson S., Gracia F., De B. K., Castillo L., Larreategui M., Roberts B. D., Levine P. H., Blattner W. A., Kaplan J. E. Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8840–8844. doi: 10.1073/pnas.87.22.8840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reeves W. C., Cutler J. R., Gracia F., Kaplan J. E., Castillo L., Hartley T. M., Brenes M. M., Larreategui M., Loo de Lao S., Archbold C. Human T cell lymphotropic virus infection in Guaymi Indians from Panama. Am J Trop Med Hyg. 1990 Oct;43(4):410–418. doi: 10.4269/ajtmh.1990.43.410. [DOI] [PubMed] [Google Scholar]
  15. Saxinger C., Gallo R. C. Methods in laboratory investigation. Application of the indirect enzyme-linked immunosorbent assay microtest to the detection and surveillance of human t cell leukemia-lymphoma virus. Lab Invest. 1983 Sep;49(3):371–377. [PubMed] [Google Scholar]
  16. Saxinger W., Blattner W. A., Levine P. H., Clark J., Biggar R., Hoh M., Moghissi J., Jacobs P., Wilson L., Jacobson R. Human T-cell leukemia virus (HTLV-I) antibodies in Africa. Science. 1984 Sep 28;225(4669):1473–1476. doi: 10.1126/science.6089348. [DOI] [PubMed] [Google Scholar]
  17. Weiss R. A., Cheingsong-Popov R., Clayden S., Pegram S., Tedder R. S., Barzilai A., Rubenstein E. Lack of HTLV-I antibodies in Africans. 1986 Feb 27-Mar 5Nature. 319(6056):794–795. doi: 10.1038/319794b0. [DOI] [PubMed] [Google Scholar]
  18. Wiktor S. Z., Alexander S. S., Shaw G. M., Weiss S. H., Murphy E. L., Wilks R. J., Shortly V. J., Hanchard B., Blattner W. A. Distinguishing between HTLV-I and HTLV-II by western blot. Lancet. 1990 Jun 23;335(8704):1533–1533. doi: 10.1016/0140-6736(90)93078-4. [DOI] [PubMed] [Google Scholar]
  19. Williams C. K., Alabi G. O., Junaid T. A., Saxinger C., Gallo R. C., Blayney D. W., Blattner W. A., Greaves M. F. Human T cell leukaemia virus associated lymphoproliferative disease: report of two cases in Nigeria. Br Med J (Clin Res Ed) 1984 May 19;288(6429):1495–1496. doi: 10.1136/bmj.288.6429.1495. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES