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. 1993 Sep;68(3):519–523. doi: 10.1038/bjc.1993.379

Molecular alterations in a patient with Turcot's syndrome.

C F Rochlitz 1, I Heide 1, E de Kant 1, A Neubauer 1, C A Schmidt 1, P Neuhaus 1, D Huhn 1, R Herrmann 1
PMCID: PMC1968408  PMID: 8394730

Abstract

Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

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Selected References

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