Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1993 May;67(5):1071–1075. doi: 10.1038/bjc.1993.196

Squamous carcinoma of the head and neck: cured fraction and median survival time as functions of age, sex, histologic type, and node status.

J W Gamel 1, A S Jones 1
PMCID: PMC1968418  PMID: 8494700

Abstract

The multivariate lognormal survival model can be used to determine the relationship of prognostic covariates to two important parameters of malignancy. Cured fraction and median survival time among uncured patients. Analysis with this model revealed that cured fraction is primarily a function of histologic type and node status, while median survival time is primarily a function of age and node status. Patient sex was also related to likelihood of cure, but this association was of marginal significance. The symmetric impact of node status on both cured fraction and median survival time is consistent with known biologic principles. The strongly asymmetric relationships of histologic grade to cured fraction and age to survival time suggest, however, that likelihood of cure and survival time may not operate by identical biologic mechanisms.

Full text

PDF
1071

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birkhead B. G. Mathematical model of remission duration in acute myelogenous leukemia. Cancer Treat Rep. 1985 Jun;69(6):595–601. [PubMed] [Google Scholar]
  2. Cook P. J., Doll R., Fellingham S. A. A mathematical model for the age distribution of cancer in man. Int J Cancer. 1969 Jan 15;4(1):93–112. doi: 10.1002/ijc.2910040113. [DOI] [PubMed] [Google Scholar]
  3. Cutler S. J., Axtell L. M., Schottenfeld D. Adjustment of long-term survival rates for deaths due to intercurrent disease. J Chronic Dis. 1969 Dec;22(6):485–491. doi: 10.1016/0021-9681(69)90010-1. [DOI] [PubMed] [Google Scholar]
  4. Gamel J. W., McLean I. W., Rosenberg S. H. Proportion cured and mean log survival time as functions of tumour size. Stat Med. 1990 Aug;9(8):999–1006. doi: 10.1002/sim.4780090814. [DOI] [PubMed] [Google Scholar]
  5. Gregory W. M., Richards M. A., Slevin M. L., Souhami R. L. A mathematical model relating response durations to amount of subclinical resistant disease. Cancer Res. 1991 Feb 15;51(4):1210–1216. [PubMed] [Google Scholar]
  6. Huygen P. L., van den Broek P., Kazem I. Age and mortality in laryngeal cancer. Clin Otolaryngol Allied Sci. 1980 Apr;5(2):129–137. doi: 10.1111/j.1365-2273.1980.tb01638.x. [DOI] [PubMed] [Google Scholar]
  7. KLEINSASSER O. [A laryngomicroscope for the early diagnosis and differential diagnosis of cancers in the larynx, pharynx and mouth]. Z Laryngol Rhinol Otol. 1961 Apr;40:276–279. [PubMed] [Google Scholar]
  8. Katz A. E. Immunobiologic staging of patients with carcinoma of the head and neck. Laryngoscope. 1983 Apr;93(4):445–463. doi: 10.1002/lary.1983.93.4.445. [DOI] [PubMed] [Google Scholar]
  9. Mould R. F., Boag J. W. A test of several parametic statistical models for estimating success rate in the treatment of carcinoma cervix uteri. Br J Cancer. 1975 Nov;32(5):529–550. doi: 10.1038/bjc.1975.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mould R. F., Hearnden T., Palmer M., White G. C. Distribution of survival times of 12,000 head and neck cancer patients who died with their disease. Br J Cancer. 1976 Aug;34(2):180–190. doi: 10.1038/bjc.1976.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. NORRIS C. M. Problems in classification and staging of cancer of the larynx. Ann Otol Rhinol Laryngol. 1963 Mar;72:83–96. doi: 10.1177/000348946307200108. [DOI] [PubMed] [Google Scholar]
  12. Pike M. C. A method of analysis of a certain class of experiments in carcinogenesis. Biometrics. 1966 Mar;22(1):142–161. [PubMed] [Google Scholar]
  13. Rutqvist L. E., Wallgren A., Nilsson B. Is breast cancer a curable disease? A study of 14,731 women with breast cancer from the Cancer Registry of Norway. Cancer. 1984 Apr 15;53(8):1793–1800. doi: 10.1002/1097-0142(19840415)53:8<1793::aid-cncr2820530832>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  14. Stell P. M. Prognosis in laryngeal carcinoma: host factors. Clin Otolaryngol Allied Sci. 1990 Apr;15(2):111–119. doi: 10.1111/j.1365-2273.1990.tb00442.x. [DOI] [PubMed] [Google Scholar]
  15. Stell P. M. Prognosis in laryngeal carcinoma: tumour factors. Clin Otolaryngol Allied Sci. 1990 Feb;15(1):69–81. doi: 10.1111/j.1365-2273.1990.tb00436.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES