Abstract
The health status of 69 survivors of high-risk acute lymphoblastic leukaemia (ALL) is assessed using a multi-attribute classification system. Seven attributes are included: sensation, mobility, emotion, cognition, self-care, pain and fertility. Three to five levels of functioning are defined for each attribute. Comprehensive health states are described as a specific combination of seven attribute levels. The system captures combinations of sequelae. The system provides a compact but comprehensive tool for long term follow up of survivors of childhood cancer. The results underscore the cognitive and emotional burdens of morbidity affecting survivors of high-risk ALL.
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Selected References
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- Barr R. D., DeVeber L. L., Pai K. M., Andrew M., Halton J., Cairney A. E., Whitton A. C. Management of children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. An update of the Ontario experience. Am J Pediatr Hematol Oncol. 1992 May;14(2):136–139. doi: 10.1097/00043426-199205000-00007. [DOI] [PubMed] [Google Scholar]
- Boyle M. H., Torrance G. W. Developing multiattribute health indexes. Med Care. 1984 Nov;22(11):1045–1057. doi: 10.1097/00005650-198411000-00007. [DOI] [PubMed] [Google Scholar]
- Boyle M. H., Torrance G. W., Sinclair J. C., Horwood S. P. Economic evaluation of neonatal intensive care of very-low-birth-weight infants. N Engl J Med. 1983 Jun 2;308(22):1330–1337. doi: 10.1056/NEJM198306023082206. [DOI] [PubMed] [Google Scholar]
- Cadman D., Goldsmith C., Bashim P. Values, Preferences, and decisions in the care of children with developmental disabilities. J Dev Behav Pediatr. 1984 Apr;5(2):60–64. [PubMed] [Google Scholar]
- Cadman D., Goldsmith C. Construction of social value or utility-based health indices: the usefulness of factorial experimental design plans. J Chronic Dis. 1986;39(8):643–651. doi: 10.1016/0021-9681(86)90189-x. [DOI] [PubMed] [Google Scholar]
- Chessells J. M., Ninane J., Tiedemann K. Present problems in management of childhood lymphoblastic leukaemia: experience from the Hospital for Sick Children, London. Haematol Blood Transfus. 1981;26:108–114. doi: 10.1007/978-3-642-67984-1_16. [DOI] [PubMed] [Google Scholar]
- Clarridge B. R., Massagli M. P. The use of female spouse proxies in common symptom reporting. Med Care. 1989 Apr;27(4):352–366. doi: 10.1097/00005650-198904000-00003. [DOI] [PubMed] [Google Scholar]
- Clayton P. E., Shalet S. M., Morris-Jones P. H., Price D. A. Growth in children treated for acute lymphoblastic leukaemia. Lancet. 1988 Feb 27;1(8583):460–462. doi: 10.1016/s0140-6736(88)91246-9. [DOI] [PubMed] [Google Scholar]
- Feeny D., Furlong W., Barr R. D., Torrance G. W., Rosenbaum P., Weitzman S. A comprehensive multiattribute system for classifying the health status of survivors of childhood cancer. J Clin Oncol. 1992 Jun;10(6):923–928. doi: 10.1200/JCO.1992.10.6.923. [DOI] [PubMed] [Google Scholar]
- Gaynon P. S. Primary treatment of childhood acute lymphoblastic leukemia of non-T cell lineage (including infants). Hematol Oncol Clin North Am. 1990 Oct;4(5):915–936. [PubMed] [Google Scholar]
- Green D. M., Zevon M. A., Hall B. Achievement of life goals by adult survivors of modern treatment for childhood cancer. Cancer. 1991 Jan 1;67(1):206–213. doi: 10.1002/1097-0142(19910101)67:1<206::aid-cncr2820670134>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Griffin N. K., Wadsworth J. Effect of treatment of malignant disease on growth in children. Arch Dis Child. 1980 Aug;55(8):600–603. doi: 10.1136/adc.55.8.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herjanic B., Reich W. Development of a structured psychiatric interview for children: agreement between child and parent on individual symptoms. J Abnorm Child Psychol. 1982 Sep;10(3):307–324. doi: 10.1007/BF00912324. [DOI] [PubMed] [Google Scholar]
- Kupst M. J., Schulman J. L. Long-term coping with pediatric leukemia: a six-year follow-up study. J Pediatr Psychol. 1988 Mar;13(1):7–22. doi: 10.1093/jpepsy/13.1.7. [DOI] [PubMed] [Google Scholar]
- Kupst M. J., Schulman J. L., Maurer H., Honig G., Morgan E., Fochtman D. Coping with pediatric leukemia: a two-year follow-up. J Pediatr Psychol. 1984 Jun;9(2):149–163. doi: 10.1093/jpepsy/9.2.149. [DOI] [PubMed] [Google Scholar]
- Lansky S. B., List M. A., Lansky L. L., Ritter-Sterr C., Miller D. R. The measurement of performance in childhood cancer patients. Cancer. 1987 Oct 1;60(7):1651–1656. doi: 10.1002/1097-0142(19871001)60:7<1651::aid-cncr2820600738>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
- Links P. S., Stockwell M. L. Obstacles in the prevention of psychological sequelae in survivors of childhood cancer. Am J Pediatr Hematol Oncol. 1985 Summer;7(2):132–140. [PubMed] [Google Scholar]
- Magaziner J., Simonsick E. M., Kashner T. M., Hebel J. R. Patient-proxy response comparability on measures of patient health and functional status. J Clin Epidemiol. 1988;41(11):1065–1074. doi: 10.1016/0895-4356(88)90076-5. [DOI] [PubMed] [Google Scholar]
- Maguire G. P. The psychological sequelae of childhood leukaemia. Recent Results Cancer Res. 1983;88:47–56. doi: 10.1007/978-3-642-82034-2_5. [DOI] [PubMed] [Google Scholar]
- Meadows A. T., Gordon J., Massari D. J., Littman P., Fergusson J., Moss K. Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukaemia treated with cranial irradiation. Lancet. 1981 Nov 7;2(8254):1015–1018. doi: 10.1016/s0140-6736(81)91216-2. [DOI] [PubMed] [Google Scholar]
- Mostow E. N., Byrne J., Connelly R. R., Mulvihill J. J. Quality of life in long-term survivors of CNS tumors of childhood and adolescence. J Clin Oncol. 1991 Apr;9(4):592–599. doi: 10.1200/JCO.1991.9.4.592. [DOI] [PubMed] [Google Scholar]
- Nesbit M. E., Krivit W., Robison L., Hammond D. A follow-up report of long-term survivors of childhood acute lymphoblastic or undifferentiated leukemia. A report for Childrens Cancer Study Group. J Pediatr. 1979 Nov;95(5 Pt 1):727–730. doi: 10.1016/s0022-3476(79)80719-2. [DOI] [PubMed] [Google Scholar]
- O'Malley J. E., Koocher G., Foster D., Slavin L. Psychiatric sequelae of surviving childhood cancer. Am J Orthopsychiatry. 1979 Oct;49(4):608–616. doi: 10.1111/j.1939-0025.1979.tb02646.x. [DOI] [PubMed] [Google Scholar]
- Rothman M. L., Hedrick S. C., Bulcroft K. A., Hickam D. H., Rubenstein L. Z. The validity of proxy-generated scores as measures of patient health status. Med Care. 1991 Feb;29(2):115–124. doi: 10.1097/00005650-199102000-00004. [DOI] [PubMed] [Google Scholar]
- Torrance G. W., Boyle M. H., Horwood S. P. Application of multi-attribute utility theory to measure social preferences for health states. Oper Res. 1982 Nov-Dec;30(6):1043–1069. doi: 10.1287/opre.30.6.1043. [DOI] [PubMed] [Google Scholar]
- Wheeler K., Leiper A. D., Jannoun L., Chessells J. M. Medical cost of curing childhood acute lymphoblastic leukaemia. Br Med J (Clin Res Ed) 1988 Jan 16;296(6616):162–166. doi: 10.1136/bmj.296.6616.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whitt J. K., Wells R. J., Lauria M. M., Wilhelm C. L., McMillan C. W. Cranial radiation in childhood acute lymphocytic leukemia. Neuropsychologic sequelae. Am J Dis Child. 1984 Aug;138(8):730–736. doi: 10.1001/archpedi.1984.02140460022009. [DOI] [PubMed] [Google Scholar]
