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. 1993 Aug;68(2):264–268. doi: 10.1038/bjc.1993.325

Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).

D M Livingston 1, W Kaelin 1, T Chittenden 1, X Qin 1
PMCID: PMC1968582  PMID: 8347480

Abstract

The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket').

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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