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. 1993 Oct;68(4):808–812. doi: 10.1038/bjc.1993.432

Prognostic impact of EGF-receptor in papillary thyroid carcinoma.

L A Akslen 1, A O Myking 1, H Salvesen 1, J E Varhaug 1
PMCID: PMC1968597  PMID: 8398712

Abstract

In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas.

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Selected References

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  1. Aasland R., Akslen L. A., Varhaug J. E., Lillehaug J. R. Co-expression of the genes encoding transforming growth factor-alpha and its receptor in papillary carcinomas of the thyroid. Int J Cancer. 1990 Sep 15;46(3):382–387. doi: 10.1002/ijc.2910460308. [DOI] [PubMed] [Google Scholar]
  2. Aasland R., Lillehaug J. R., Male R., Jøsendal O., Varhaug J. E., Kleppe K. Expression of oncogenes in thyroid tumours: coexpression of c-erbB2/neu and c-erbB. Br J Cancer. 1988 Apr;57(4):358–363. doi: 10.1038/bjc.1988.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Akslen L. A., Haldorsen T., Thoresen S. O., Glattre E. Survival and causes of death in thyroid cancer: a population-based study of 2479 cases from Norway. Cancer Res. 1991 Feb 15;51(4):1234–1241. [PubMed] [Google Scholar]
  4. Akslen L. A., Myking A. O., Salvesen H., Varhaug J. E. Prognostic importance of various clinicopathological features in papillary thyroid carcinoma. Eur J Cancer. 1992;29A(1):44–51. doi: 10.1016/0959-8049(93)90574-y. [DOI] [PubMed] [Google Scholar]
  5. Bolla M., Chedin M., Colonna M., Marron J., Rostaing-Puissant B., Chambaz E. Prognostic value of epidermal growth factor receptor in a series of 303 breast cancers. Eur J Cancer. 1992;28A(6-7):1052–1054. doi: 10.1016/0959-8049(92)90454-a. [DOI] [PubMed] [Google Scholar]
  6. Boyd D. Examination of the effects of epidermal growth factor on the production of urokinase and the expression of the plasminogen activator receptor in a human colon cancer cell line. Cancer Res. 1989 May 1;49(9):2427–2432. [PubMed] [Google Scholar]
  7. Byar D. P., Green S. B., Dor P., Williams E. D., Colon J., van Gilse H. A., Mayer M., Sylvester R. J., van Glabbeke M. A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. Thyroid Cancer Cooperative Group. Eur J Cancer. 1979 Aug;15(8):1033–1041. doi: 10.1016/0014-2964(79)90291-3. [DOI] [PubMed] [Google Scholar]
  8. Carcangiu M. L., Zampi G., Pupi A., Castagnoli A., Rosai J. Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer. 1985 Feb 15;55(4):805–828. doi: 10.1002/1097-0142(19850215)55:4<805::aid-cncr2820550419>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  9. Carpenter G., Cohen S. Epidermal growth factor. Annu Rev Biochem. 1979;48:193–216. doi: 10.1146/annurev.bi.48.070179.001205. [DOI] [PubMed] [Google Scholar]
  10. Di Carlo A., Mariano A., Pisano G., Parmeggiani U., Beguinot L., Macchia V. Epidermal growth factor receptor and thyrotropin response in human thyroid tissues. J Endocrinol Invest. 1990 Apr;13(4):293–299. doi: 10.1007/BF03349565. [DOI] [PubMed] [Google Scholar]
  11. Duh Q. Y., Gum E. T., Gerend P. L., Raper S. E., Clark O. H. Epidermal growth factor receptors in normal and neoplastic thyroid tissue. Surgery. 1985 Dec;98(6):1000–1007. [PubMed] [Google Scholar]
  12. Fitzpatrick S. L., Brightwell J., Wittliff J. L., Barrows G. H., Schultz G. S. Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels. Cancer Res. 1984 Aug;44(8):3448–3453. [PubMed] [Google Scholar]
  13. Grimaux M., Romain S., Remvikos Y., Martin P. M., Magdelénat H. Prognostic value of epidermal growth factor receptor in node-positive breast cancer. Breast Cancer Res Treat. 1989 Oct;14(1):77–90. doi: 10.1007/BF01805978. [DOI] [PubMed] [Google Scholar]
  14. Haugen D. R., Akslen L. A., Varhaug J. E., Lillehaug J. R. Expression of c-erbB-2 protein in papillary thyroid carcinomas. Br J Cancer. 1992 Jun;65(6):832–837. doi: 10.1038/bjc.1992.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lee L. S., Weinstein I. B. Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells. Nature. 1978 Aug 17;274(5672):696–697. doi: 10.1038/274696a0. [DOI] [PubMed] [Google Scholar]
  16. Lemoine N. R., Hughes C. M., Gullick W. J., Brown C. L., Wynford-Thomas D. Abnormalities of the EGF receptor system in human thyroid neoplasia. Int J Cancer. 1991 Oct 21;49(4):558–561. doi: 10.1002/ijc.2910490414. [DOI] [PubMed] [Google Scholar]
  17. Lemoine N. R., Wyllie F. S., Lillehaug J. R., Staddon S. L., Hughes C. M., Aasland R., Shaw J., Varhaug J. E., Brown C. L., Gullick W. J. Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia. Eur J Cancer. 1990;26(7):777–779. doi: 10.1016/0277-5379(90)90149-n. [DOI] [PubMed] [Google Scholar]
  18. Masuda H., Sugenoya A., Kobayashi S., Kasuga Y., Iida F. Epidermal growth factor receptor on human thyroid neoplasms. World J Surg. 1988 Oct;12(5):616–622. doi: 10.1007/BF01655864. [DOI] [PubMed] [Google Scholar]
  19. Mizukami Y., Nonomura A., Hashimoto T., Michigishi T., Noguchi M., Matsubara F., Yanaihara N. Immunohistochemical demonstration of epidermal growth factor and c-myc oncogene product in normal, benign and malignant thyroid tissues. Histopathology. 1991 Jan;18(1):11–18. doi: 10.1111/j.1365-2559.1991.tb00808.x. [DOI] [PubMed] [Google Scholar]
  20. Mäkinen T., Pekonen F., Franssila K., Lamberg B. A. Receptors for epidermal growth factor and thyrotropin in thyroid carcinoma. Acta Endocrinol (Copenh) 1988 Jan;117(1):45–50. doi: 10.1530/acta.0.1170045. [DOI] [PubMed] [Google Scholar]
  21. Neal D. E., Marsh C., Bennett M. K., Abel P. D., Hall R. R., Sainsbury J. R., Harris A. L. Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet. 1985 Feb 16;1(8425):366–368. doi: 10.1016/s0140-6736(85)91386-8. [DOI] [PubMed] [Google Scholar]
  22. Nicholson S., Richard J., Sainsbury C., Halcrow P., Kelly P., Angus B., Wright C., Henry J., Farndon J. R., Harris A. L. Epidermal growth factor receptor (EGFr); results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroup. Br J Cancer. 1991 Jan;63(1):146–150. doi: 10.1038/bjc.1991.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sainsbury J. R., Farndon J. R., Needham G. K., Malcolm A. J., Harris A. L. Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet. 1987 Jun 20;1(8547):1398–1402. doi: 10.1016/s0140-6736(87)90593-9. [DOI] [PubMed] [Google Scholar]
  24. Schindler A. M., van Melle G., Evequoz B., Scazziga B. Prognostic factors in papillary carcinoma of the thyroid. Cancer. 1991 Jul 15;68(2):324–330. doi: 10.1002/1097-0142(19910715)68:2<324::aid-cncr2820680220>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  25. Smith K., Fennelly J. A., Neal D. E., Hall R. R., Harris A. L. Characterization and quantitation of the epidermal growth factor receptor in invasive and superficial bladder tumors. Cancer Res. 1989 Nov 1;49(21):5810–5815. [PubMed] [Google Scholar]
  26. Song B. Immunohistochemical demonstration of epidermal growth factor receptor and ceruloplasmin in thyroid diseases. Acta Pathol Jpn. 1991 May;41(5):336–343. doi: 10.1111/j.1440-1827.1991.tb01656.x. [DOI] [PubMed] [Google Scholar]
  27. Tennvall J., Biörklund A., Möller T., Ranstam J., Akerman M. Prognostic factors of papillary, follicular and medullary carcinomas of the thyroid gland. Retrospective multivariate analysis of 216 patients with a median follow-up of 11 years. Acta Radiol Oncol. 1985 Jan-Feb;24(1):17–24. doi: 10.3109/02841868509134360. [DOI] [PubMed] [Google Scholar]
  28. Toi M., Osaki A., Yamada H., Toge T. Epidermal growth factor receptor expression as a prognostic indicator in breast cancer. Eur J Cancer. 1991;27(8):977–980. doi: 10.1016/0277-5379(91)90262-c. [DOI] [PubMed] [Google Scholar]
  29. Tubiana M., Schlumberger M., Rougier P., Laplanche A., Benhamou E., Gardet P., Caillou B., Travagli J. P., Parmentier C. Long-term results and prognostic factors in patients with differentiated thyroid carcinoma. Cancer. 1985 Feb 15;55(4):794–804. doi: 10.1002/1097-0142(19850215)55:4<794::aid-cncr2820550418>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  30. Westermark B., Magnusson A., Heldin C. H. Effect of epidermal growth factor on membrane motility and cell locomotion in cultures of human clonal glioma cells. J Neurosci Res. 1982;8(2-3):491–507. doi: 10.1002/jnr.490080236. [DOI] [PubMed] [Google Scholar]
  31. Wynford-Thomas D. Oncogenes and anti-oncogenes; the molecular basis of tumour behaviour. J Pathol. 1991 Nov;165(3):187–201. doi: 10.1002/path.1711650302. [DOI] [PubMed] [Google Scholar]
  32. Yasui W., Sumiyoshi H., Hata J., Kameda T., Ochiai A., Ito H., Tahara E. Expression of epidermal growth factor receptor in human gastric and colonic carcinomas. Cancer Res. 1988 Jan 1;48(1):137–141. [PubMed] [Google Scholar]
  33. Yonemura Y., Sugiyama K., Fushida S., Kamata T., Ohoyama S., Kimura H., Yamaguchi A., Miyazaki I. Tissue status of epidermal growth factor and its receptor as an indicator of poor prognosis in patients with gastric cancer. Anal Cell Pathol. 1991 Nov;3(6):343–350. [PubMed] [Google Scholar]

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