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editorial
. 1993 Dec;68(6):1047–1050. doi: 10.1038/bjc.1993.481

Stopping rules, interim analyses and data monitoring committees.

D Ashby, D Machin
PMCID: PMC1968643  PMID: 8260354

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkins H., Hayward J. L., Klugman D. J., Wayte A. B. Treatment of early breast cancer: a report after ten years of a clinical trial. Br Med J. 1972 May 20;2(5811):423–429. doi: 10.1136/bmj.2.5811.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brinkley D., Haybittle S. L. Treatment of stage-II carcinoma of the female breast. Lancet. 1966 Aug 6;2(7458):291–295. doi: 10.1016/s0140-6736(66)92590-6. [DOI] [PubMed] [Google Scholar]
  3. Dillman R. O., Seagren S. L., Propert K. J., Guerra J., Eaton W. L., Perry M. C., Carey R. W., Frei E. F., 3rd, Green M. R. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med. 1990 Oct 4;323(14):940–945. doi: 10.1056/NEJM199010043231403. [DOI] [PubMed] [Google Scholar]
  4. Dixon A. R., Jackson L., Chan S., Haybittle J., Blamey R. W. A randomised trial of second-line hormone vs single agent chemotherapy in tamoxifen resistant advanced breast cancer. Br J Cancer. 1992 Aug;66(2):402–404. doi: 10.1038/bjc.1992.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Donaldson A. N., Whitehead J., Stephens R., Machin D. A simulated sequential analysis based on data from two MRC trials. Br J Cancer. 1993 Dec;68(6):1171–1178. doi: 10.1038/bjc.1993.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Emerson S. S., Fleming T. R. Interim analyses in clinical trials. Oncology (Williston Park) 1990 Mar;4(3):126-33; discussion 134, 136. [PubMed] [Google Scholar]
  7. Errington R. D., Ashby D., Gore S. M., Abrams K. R., Myint S., Bonnett D. E., Blake S. W., Saxton T. E. High energy neutron treatment for pelvic cancers: study stopped because of increased mortality. BMJ. 1991 May 4;302(6784):1045–1051. doi: 10.1136/bmj.302.6784.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fleming T. R., Watelet L. F. Approaches to monitoring clinical trials. J Natl Cancer Inst. 1989 Feb 1;81(3):188–193. doi: 10.1093/jnci/81.3.188. [DOI] [PubMed] [Google Scholar]
  9. Fletcher A., Gore S., Jones D., Fitzpatrick R., Spiegelhalter D., Cox D. Quality of life measures in health care. II: Design, analysis, and interpretation. BMJ. 1992 Nov 7;305(6862):1145–1148. doi: 10.1136/bmj.305.6862.1145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Freedman B. Equipoise and the ethics of clinical research. N Engl J Med. 1987 Jul 16;317(3):141–145. doi: 10.1056/NEJM198707163170304. [DOI] [PubMed] [Google Scholar]
  11. Freedman L. S., Spiegelhalter D. J. Comparison of Bayesian with group sequential methods for monitoring clinical trials. Control Clin Trials. 1989 Dec;10(4):357–367. doi: 10.1016/0197-2456(89)90001-9. [DOI] [PubMed] [Google Scholar]
  12. Geller N. L., Pocock S. J. Interim analyses in randomized clinical trials: ramifications and guidelines for practitioners. Biometrics. 1987 Mar;43(1):213–223. [PubMed] [Google Scholar]
  13. Gray R., James R., Mossman J., Stenning S. AXIS--a suitable case for treatment. UK Coordinating Committee on Cancer Research (UKCCCR) Colorectal Cancer Subcommittee. Br J Cancer. 1991 Jun;63(6):841–845. doi: 10.1038/bjc.1991.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hampton J. R., Julian D. G. Role of the pharmaceutical industry in major clinical trials. Lancet. 1987 Nov 28;2(8570):1258–1259. doi: 10.1016/s0140-6736(87)91863-0. [DOI] [PubMed] [Google Scholar]
  15. KAAE S., JOHANSEN H. Breast cancer; five year results: two random series of simple mastectomy with postoperative irradiation versus extended radical mastectomy. Am J Roentgenol Radium Ther Nucl Med. 1962 Jan;87:82–88. [PubMed] [Google Scholar]
  16. Meier P. Terminating a trial -- the ethical problem. Clin Pharmacol Ther. 1979 May;25(5 Pt 2):633–640. doi: 10.1002/cpt1979255part2633. [DOI] [PubMed] [Google Scholar]
  17. Moertel C. G., Fleming T. R., Macdonald J. S., Haller D. G., Laurie J. A., Goodman P. J., Ungerleider J. S., Emerson W. A., Tormey D. C., Glick J. H. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990 Feb 8;322(6):352–358. doi: 10.1056/NEJM199002083220602. [DOI] [PubMed] [Google Scholar]
  18. Parmar M. K., Machin D. Monitoring clinical trials: experience of, and proposals under consideration by, the Cancer Therapy Committee of the British Medical Research Council. Stat Med. 1993 Mar;12(5-6):497–504. doi: 10.1002/sim.4780120515. [DOI] [PubMed] [Google Scholar]
  19. Pocock S. J., Hughes M. D., Lee R. J. Statistical problems in the reporting of clinical trials. A survey of three medical journals. N Engl J Med. 1987 Aug 13;317(7):426–432. doi: 10.1056/NEJM198708133170706. [DOI] [PubMed] [Google Scholar]
  20. Pocock S. J. Size of cancer clinical trials and stopping rules. Br J Cancer. 1978 Dec;38(6):757–766. doi: 10.1038/bjc.1978.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Pocock S. J. When to stop a clinical trial. BMJ. 1992 Jul 25;305(6847):235–240. doi: 10.1136/bmj.305.6847.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Souhami R. L., Spiro S. G., Cullen M. Chemotherapy and radiation therapy as compared with radiation therapy in stage III non-small-cell cancer. N Engl J Med. 1991 Apr 18;324(16):1136–1137. doi: 10.1056/NEJM199104183241614. [DOI] [PubMed] [Google Scholar]
  23. Tannock I. F., Boyer M. When is a cancer treatment worthwhile? N Engl J Med. 1990 Oct 4;323(14):989–990. doi: 10.1056/NEJM199010043231410. [DOI] [PubMed] [Google Scholar]
  24. Thompson S. G., Pocock S. J. Can meta-analyses be trusted? Lancet. 1991 Nov 2;338(8775):1127–1130. doi: 10.1016/0140-6736(91)91975-z. [DOI] [PubMed] [Google Scholar]
  25. Whitehead J. Interim analyses and stopping rules in cancer clinical trials. Br J Cancer. 1993 Dec;68(6):1179–1185. doi: 10.1038/bjc.1993.500. [DOI] [PMC free article] [PubMed] [Google Scholar]

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