Abstract
Nebulisation chemotherapy, a chemotherapeutic method for the treatment of lung cancer that involves the administration of anticancer agents through the inhalation of nebulised aerosols, has been found to be highly effective (Tatsumura et al., 1983a,b). We confirmed that 5-FU administered by this method accumulates in the trachea, bronchi and regional lymph nodes of patients treated before surgery, along with 5-FU metabolites, FUR and FUdR, indicating that 5-FU is directly incorporated and metabolised in the respiratory tract. Parallel result were obtained using mongrel dogs. The 5-FU levels in other organs, such as the heart and liver, were found to be extremely low. Only a trace of 5-FU was found in the serum of both the patients and the dogs. We further investigated the anti-tumour effect of this therapy in ten selected patients and observed a satisfactory anti-tumour response of 60.0%. These results, along with our previous finding that the retention time of isotope tracers inhaled as aerosol is considerably longer in tumour tissues than in normal parts (Tatsumura et al., 1983a) explain the high antitumour action of this therapy and the absence of adverse effects of administered 5-FU.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAGSHAW M. A. Approaches for combined radiation and chemotherapy. Laval Med. 1963 Jan;34:124–133. [PubMed] [Google Scholar]
- Bruce W. R. The action of chemotherapeutic agents at the cellular level and the effects of these agents on hematopoietic and lymphomatous tissue. Proc Can Cancer Conf. 1967;7:53–64. [PubMed] [Google Scholar]
- GOLLIN F. F., ANSFIELD F. J., CURRERI A. R., HEIDELBERGER C., VERMUND H. Combined chemotherapy and irradiation in inoperable bronchogenic carcinoma. Cancer. 1962 Nov-Dec;15:1209–1217. doi: 10.1002/1097-0142(196211/12)15:6<1209::aid-cncr2820150618>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- LOWRY G. M. ADDITIVE CYTOTOXICITY OF 5-FLUOROURACIL AND GAMMA-RADIATION ON DIPLOID CELL STRAINS. Cancer Res. 1965 Jun;25:760–763. [PubMed] [Google Scholar]
- Masuike T., Watanabe I., Takemoto Y. [Quantitative method of 5-fluorouracil and its metabolites in biological samples using high performance liquid chromatography]. Yakugaku Zasshi. 1985 Nov;105(11):1058–1064. doi: 10.1248/yakushi1947.105.11_1058. [DOI] [PubMed] [Google Scholar]
- Skipper H. E., Schabel F. M., Jr, Mellett L. B., Montgomery J. A., Wilkoff L. J., Lloyd H. H., Brockman R. W. Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules. Cancer Chemother Rep. 1970 Dec;54(6):431–450. [PubMed] [Google Scholar]
- Tatsumura T., Yamamoto K., Murakami A., Tsuda M., Sugiyama S. [New chemotherapeutic method for the treatment of tracheal and bronchial cancers--nebulization chemotherapy]. Gan No Rinsho. 1983 Jun;29(7):765–770. [PubMed] [Google Scholar]
- Wolfsdorf J., Swift D. L., Avery M. E. Mist therapy reconsidered; an evaluation of the respiratory deposition of labelled water aerosols produced by jet and ultrasonic nebulizers. Pediatrics. 1969 May;43(5):799–808. [PubMed] [Google Scholar]