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. 1994 Jun;69(6):1098–1101. doi: 10.1038/bjc.1994.215

Long-term survival of stage A prostate carcinoma, atypical hyperplasia/adenosis and BPH.

P N Brawn 1, E H Johnson 1, V O Speights 1, M Riggs 1, M Lind 1, N Bell 1
PMCID: PMC1969422  PMID: 7515262

Abstract

Between 1972 and 1986, 134 patients with stage A carcinoma of the prostate (CAP) were diagnosed at a single Veterans Administration medical centre and followed annually by the hospital tumour registry. Seventy-four were classified as stage A1, defined as non-palpable, well-differentiated CAP, regardless of amount, found unexpectedly on transurethral resection of the prostate (TURP). Twenty-eight were classified as stage A2, defined as non-palpable, moderately or poorly differentiated CAP, regardless of amount, found unexpectedly on TURP. The remaining 32 were reclassified as atypical hyperplasia/adenosis (AH/A) rather than CAP. The survival of each group was compared with the survival of a control group from the same medical centre who had TURPs showing histologically proven benign prostatic hyperplasia (BPH). Survival and tumour progression were similar for patients with stage A1 CAP, AH/A and BPH. Furthermore, patients with stage A1 CAP, with or without therapy, had similar survivals as patients with BPH in each age group (under 65, 65-74 and over 74 years). Stage A2 CAP was associated with a significantly worse survival and more tumour progression. Within stage A1 CAP and stage A2 CAP the percentage of chips with CAP or the amount of CAP removed did not affect survival.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blute M. L., Zincke H., Farrow G. M. Long-term followup of young patients with stage A adenocarcinoma of the prostate. J Urol. 1986 Oct;136(4):840–843. doi: 10.1016/s0022-5347(17)45098-1. [DOI] [PubMed] [Google Scholar]
  2. Bostwick D. G., Srigley J., Grignon D., Maksem J., Humphrey P., van der Kwast T. H., Bose D., Harrison J., Young R. H. Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma. Hum Pathol. 1993 Aug;24(8):819–832. doi: 10.1016/0046-8177(93)90131-y. [DOI] [PubMed] [Google Scholar]
  3. Brawn P. N. Adenosis of the prostate: a dysplastic lesion that can be confused with prostate adenocarcinoma. Cancer. 1982 Feb 15;49(4):826–833. doi: 10.1002/1097-0142(19820215)49:4<826::aid-cncr2820490436>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  4. Brawn P. N., Ayala A. G., Von Eschenbach A. C., Hussey D. H., Johnson D. E. Histologic grading study of prostate adenocarcinoma: the development of a new system and comparison with other methods--a preliminary study. Cancer. 1982 Feb 1;49(3):525–532. doi: 10.1002/1097-0142(19820201)49:3<525::aid-cncr2820490321>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  5. Brawn P. N., Speights V. O., Kuhl D., Riggs M., Spiekerman A. M., McCord R. G., Coffield K. S., Stewart D. T., Lind M. L. Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates. Cancer. 1991 Oct 1;68(7):1592–1599. doi: 10.1002/1097-0142(19911001)68:7<1592::aid-cncr2820680721>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  6. Brawn P. Histologic features of metastatic prostate cancer. Hum Pathol. 1992 Mar;23(3):267–272. doi: 10.1016/0046-8177(92)90107-e. [DOI] [PubMed] [Google Scholar]
  7. Brawn P., Kuhl D., Johnson C., 3rd, Pandya P., McCord R. Stage D1 prostate carcinoma. The histologic appearance of nodal metastases and its relationship to survival. Cancer. 1990 Feb 1;65(3):538–543. doi: 10.1002/1097-0142(19900201)65:3<538::aid-cncr2820650326>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  8. Cantrell B. B., DeKlerk D. P., Eggleston J. C., Boitnott J. K., Walsh P. C. Pathological factors that influence prognosis in stage A prostatic cancer: the influence of extent versus grade. J Urol. 1981 Apr;125(4):516–520. doi: 10.1016/s0022-5347(17)55092-2. [DOI] [PubMed] [Google Scholar]
  9. Correa R. J., Jr, Anderson R. G., Gibbons R. P., Mason J. T. Latent carcinoma of the prostate--why the controversy? J Urol. 1974 May;111(5):644–646. doi: 10.1016/s0022-5347(17)60036-3. [DOI] [PubMed] [Google Scholar]
  10. Epstein J. I., Paull G., Eggleston J. C., Walsh P. C. Prognosis of untreated stage A1 prostatic carcinoma: a study of 94 cases with extended followup. J Urol. 1986 Oct;136(4):837–839. doi: 10.1016/s0022-5347(17)45097-x. [DOI] [PubMed] [Google Scholar]
  11. Greenwald P., Kirmss V., Polan A. K., Dick V. S. Cancer of the prostate among men with benign prostatic hyperplasia. J Natl Cancer Inst. 1974 Aug;53(2):335–340. doi: 10.1093/jnci/53.2.335. [DOI] [PubMed] [Google Scholar]
  12. Heaney J. A., Chang H. C., Daly J. J., Prout G. R., Jr Prognosis of clinically undiagnosed prostatic carcinoma and the influence of endocrine therapy. J Urol. 1977 Aug;118(2):283–287. doi: 10.1016/s0022-5347(17)57974-4. [DOI] [PubMed] [Google Scholar]
  13. Helpap B. The biological significance of atypical hyperplasia of the prostate. Virchows Arch A Pathol Anat Histol. 1980;387(3):307–317. doi: 10.1007/BF00454834. [DOI] [PubMed] [Google Scholar]
  14. Johansson J. E., Adami H. O., Andersson S. O., Bergström R., Holmberg L., Krusemo U. B. High 10-year survival rate in patients with early, untreated prostatic cancer. JAMA. 1992 Apr 22;267(16):2191–2196. [PubMed] [Google Scholar]
  15. Jones G. W. Prospective, conservative management of localized prostate cancer. Cancer. 1992 Jul 1;70(1 Suppl):307–310. doi: 10.1002/1097-0142(19920701)70:1+<307::aid-cncr2820701319>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  16. McNeal J. E., Bostwick D. G., Kindrachuk R. A., Redwine E. A., Freiha F. S., Stamey T. A. Patterns of progression in prostate cancer. Lancet. 1986 Jan 11;1(8472):60–63. doi: 10.1016/s0140-6736(86)90715-4. [DOI] [PubMed] [Google Scholar]
  17. McNeal J. E. Normal histology of the prostate. Am J Surg Pathol. 1988 Aug;12(8):619–633. doi: 10.1097/00000478-198808000-00003. [DOI] [PubMed] [Google Scholar]

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