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. 1994 Jun;69(6):1025–1026. doi: 10.1038/bjc.1994.201

Splanchnic blood flow changes in the presence of hepatic tumour: evidence of a humoral mediator.

R Carter 1, J H Anderson 1, T G Cooke 1, J N Baxter 1, W J Angerson 1
PMCID: PMC1969452  PMID: 8198964

Abstract

Intrahepatic tumour is associated with alterations in splanchnic haemodynamics. To investigate the hypothesis that these are the result of a circulating vasoactive agent, rat small bowel segments were cross-perfused with arterial blood from groups (n = 12) of paired tumour-bearing (intrahepatic HSN sarcoma) and control rats. The vascular resistance of the segment was significantly greater during perfusion by tumour-bearing animals (91.6 mmHg ml-1 min, s.e. 21.5, vs 51.7 mmHg ml-1 min, s.e. 7.4, P < 0.05), suggesting that intrahepatic tumour may be associated with a circulating vasoactive agent. A similar mechanism may underlie changes in the hepatic perfusion index in patients with liver metastases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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