Abstract
Coal tar, a tumour initiator, and dithranol, a tumour promoter, are used in the treatment of psoriasis. Topical treatment of mice with pharmaceutical formulations of these two agents, at therapeutic doses, induced skin papillomas in a classical two-stage carcinogenesis protocol, while treatment with either agent alone did not. This finding has implications for the use of both agents in combination in the treatment of psoriasis.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC publication no. 6: do treatments available for psoriasis patients carry a genetic or carcinogenic risk? Mutat Res. 1981 May;86(3):279–304. [PubMed] [Google Scholar]
- Phillips D. H., Hewer A., Grover P. L. Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes. Carcinogenesis. 1986 Dec;7(12):2071–2075. doi: 10.1093/carcin/7.12.2071. [DOI] [PubMed] [Google Scholar]
- Pittelkow M. R., Perry H. O., Muller S. A., Maughan W. Z., O'Brien P. C. Skin cancer in patients with psoriasis treated with coal tar. A 25-year follow-up study. Arch Dermatol. 1981 Aug;117(8):465–468. [PubMed] [Google Scholar]
- Schoket B., Hewer A., Grover P. L., Phillips D. H. Covalent binding of components of coal-tar, creosote and bitumen to the DNA of the skin and lungs of mice following topical application. Carcinogenesis. 1988 Jul;9(7):1253–1258. doi: 10.1093/carcin/9.7.1253. [DOI] [PubMed] [Google Scholar]
- Schoket B., Horkay I., Kósa A., Páldeák L., Hewer A., Grover P. L., Phillips D. H. Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture, and in mouse skin and lung following topical application of coal-tar and juniper tar. J Invest Dermatol. 1990 Feb;94(2):241–246. doi: 10.1111/1523-1747.ep12874576. [DOI] [PubMed] [Google Scholar]
- Stern R. S., Zierler S., Parrish J. A. Skin carcinoma in patients with psoriasis treated with topical tar and artificial ultraviolet radiation. Lancet. 1980 Apr 5;1(8171):732–735. doi: 10.1016/s0140-6736(80)91231-3. [DOI] [PubMed] [Google Scholar]
- Viluksela M., Puotunen E., Newman A. J., Männistö P. T. Tumor-producing and skin-irritating activity of dithranol (anthralin) and its 10-acyl analogues in SENCAR mice. Carcinogenesis. 1986 Oct;7(10):1755–1760. doi: 10.1093/carcin/7.10.1755. [DOI] [PubMed] [Google Scholar]
- Wolff K. Side-effects of psoralen photochemotherapy (PUVA). Br J Dermatol. 1990 Jun;122 (Suppl 36):117–125. doi: 10.1111/j.1365-2133.1990.tb02889.x. [DOI] [PubMed] [Google Scholar]
- Young E., van Weelden H. Treatment of psoriasis with a combination of dithranol and coal tar. Br J Dermatol. 1987 Feb;116(2):281–282. doi: 10.1111/j.1365-2133.1987.tb05835.x. [DOI] [PubMed] [Google Scholar]