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. 1994 Jun;69(6):1102–1105. doi: 10.1038/bjc.1994.216

Case-control study of gastric cancer screening in Venezuela.

P Pisani 1, W E Oliver 1, D M Parkin 1, N Alvarez 1, J Vivas 1
PMCID: PMC1969457  PMID: 8198977

Abstract

A screening programme for early gastric cancer was introduced in the state of Tachira, Venezuela, in 1980. Screening was performed by photofluorography, using two mobile units. The efficacy of this programme in reducing mortality from stomach cancer was evaluated by means of a case-control study. Cases were 241 individuals who died from stomach cancer in the period 1985-89. Ten live controls per case were drawn from the electoral rolls, matched by sex, age and residence. Exposure to the screening examination of cases and controls was assessed through individual linkage with the programme's centralised database. After the exclusion of examinations occurring within the 6 months preceding the case's diagnosis, the odds ratio (OR) of dying from stomach cancer for those screened was 1.26 (CI 0.83-1.91) and the OR in females was lower than in males: 0.77 (CI 0.33-1.78) and 1.52 (CI 0.94-2.47) respectively. Odds ratios associated with years since last test and number of tests did not differ significantly from 1. These results show the inefficacy of the programme in reducing mortality from gastric cancer in the area. In an attempt to determine whether this result was due to selection bias, an analysis restricted to subjects who had been screened at least once was performed. When examinations occurring after an index date at various intervals before the case's diagnosis were excluded, the screening test appeared to protect from death, although confidence intervals of the odds ratios are large, for example OR = 0.47 (CI 0.24-0.98) when excluding tests within 1 month.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chamberlain J., Day N. E., Hakama M., Miller A. B., Prorok P. C. UICC workshop of the Project on Evaluation of Screening Programmes for Gastrointestinal Cancer. Int J Cancer. 1986 Mar 15;37(3):329–334. doi: 10.1002/ijc.2910370302. [DOI] [PubMed] [Google Scholar]
  2. Connor R. J., Prorok P. C., Weed D. L. The case-control design and the assessment of the efficacy of cancer screening. J Clin Epidemiol. 1991;44(11):1215–1221. doi: 10.1016/0895-4356(91)90154-2. [DOI] [PubMed] [Google Scholar]
  3. Correa P., Haenszel W., Cuello C., Zavala D., Fontham E., Zarama G., Tannenbaum S., Collazos T., Ruiz B. Gastric precancerous process in a high risk population: cross-sectional studies. Cancer Res. 1990 Aug 1;50(15):4731–4736. [PubMed] [Google Scholar]
  4. Friedman D. R., Dubin N. Case-control evaluation of breast cancer screening efficacy. Am J Epidemiol. 1991 May 15;133(10):974–984. doi: 10.1093/oxfordjournals.aje.a115817. [DOI] [PubMed] [Google Scholar]
  5. Hisamichi S. Screening for gastric cancer. World J Surg. 1989 Jan-Feb;13(1):31–37. doi: 10.1007/BF01671151. [DOI] [PubMed] [Google Scholar]
  6. Miller A. B., Chamberlain J., Day N. E., Hakama M., Prorok P. C. Report on a Workshop of the UICC Project on Evaluation of Screening for Cancer. Int J Cancer. 1990 Nov 15;46(5):761–769. doi: 10.1002/ijc.2910460502. [DOI] [PubMed] [Google Scholar]
  7. Moss S. M. Case-control studies of screening. Int J Epidemiol. 1991 Mar;20(1):1–6. doi: 10.1093/ije/20.1.1. [DOI] [PubMed] [Google Scholar]
  8. Oshima A., Hirata N., Ubukata T., Umeda K., Fujimoto I. Evaluation of a mass screening program for stomach cancer with a case-control study design. Int J Cancer. 1986 Dec 15;38(6):829–833. doi: 10.1002/ijc.2910380608. [DOI] [PubMed] [Google Scholar]
  9. Palli D., Del Turco M. R., Buiatti E., Carli S., Ciatto S., Toscani L., Maltoni G. A case-control study of the efficacy of a non-randomized breast cancer screening program in Florence (Italy). Int J Cancer. 1986 Oct 15;38(4):501–504. doi: 10.1002/ijc.2910380408. [DOI] [PubMed] [Google Scholar]
  10. Parkin D. M., Lärä E., Muir C. S. Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer. 1988 Feb 15;41(2):184–197. doi: 10.1002/ijc.2910410205. [DOI] [PubMed] [Google Scholar]
  11. Weiss N. S., McKnight B., Stevens N. G. Approaches to the analysis of case-control studies of the efficacy of screening for cancer. Am J Epidemiol. 1992 Apr 1;135(7):817–823. doi: 10.1093/oxfordjournals.aje.a116368. [DOI] [PubMed] [Google Scholar]

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