Figure 1.

DNA sequence of mutations found in patients with RP (A) and patients with LCA (B). In each panel, the left sequence with the heading “control” is the wild type and the right sequence is that of an index patient whose identification number is at the top and the mutation at the bottom. All sequences are in the sense direction going from bottom to top, except the sequence showing the frameship mutation E404(4-bp ins) in patient 003–117, which is in the antisense direction from bottom to top. Patients 003–117, 003–119, and 003–179 are the index patients with RP from families 7828, 0356, and E070, respectively. Patients 048–040, 048–017, 048–054, 048–011, 048–033, 048–041, and 048–008 are the index patients with LCA from families 9404, 9148, 7775, 3867, 9190, 0748, and 9145, respectively.