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. 1990 Mar;61(3):425–428. doi: 10.1038/bjc.1990.93

Cytogenetic study in therapy-related myelodysplastic syndromes (t-MDS) and acute non-lymphocytic leukaemia (t-ANLL).

G Sozzi 1, M Miozzo 1, A Orazi 1, C Calderone 1, M Castellano 1, S Viviani 1, A Santoro 1, M A Pierotti 1, G Della Porta 1
PMCID: PMC1971308  PMID: 2328210

Abstract

A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or RT for Hodgkin's disease (eight cases), solid tumours (three cases) and multiple myeloma (one case). Clonal chromosome abnormalities were found in bone marrow or peripheral blood cells in all the 12 cases. Five patients had a clonal abnormality of chromosome no. 5 (monosomy, deletions, translocation and inversion of 5q). The critical region on chromosome no. 5 comprised bands q12-q34. Monosomy and deletion of chromosome 7q was observed in the other two patients. In the six remaining patients various karyotypic patterns were observed including a t(4;11) (q21;q23) in one case, monosomies (four cases) and trisomies (one case) of different chromosomes. In the other 15 cases, the presence of a normal karyotype together with the morphological and immunophenotypical characterisation was consistent with a diagnosis of non-neoplastic specimens.

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Selected References

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  1. Anderson R. L., Bagby G. C., Jr, Richert-Boe K., Magenis R. E., Koler R. D. Therapy-related preleukemic syndrome. Cancer. 1981 Apr 1;47(7):1867–1871. doi: 10.1002/1097-0142(19810401)47:7<1867::aid-cncr2820470725>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  2. Gomez G. A., Aggarwal K. K., Han T. Post-therapeutic acute malignant myeloproliferative syndrome and acute nonlymphocytic leukemia in non-Hodgkin's lymphoma. Cancer. 1982 Dec 1;50(11):2285–2288. doi: 10.1002/1097-0142(19821201)50:11<2285::aid-cncr2820501111>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  3. Iurlo A., Mecucci C., Van Orshoven A., Michaux J. L., Boogaerts M., Van den Berghe H. The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients. Cancer Genet Cytogenet. 1988 Dec;36(2):165–172. doi: 10.1016/0165-4608(88)90140-9. [DOI] [PubMed] [Google Scholar]
  4. Le Beau M. M., Albain K. S., Larson R. A., Vardiman J. W., Davis E. M., Blough R. R., Golomb H. M., Rowley J. D. Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol. 1986 Mar;4(3):325–345. doi: 10.1200/JCO.1986.4.3.325. [DOI] [PubMed] [Google Scholar]
  5. Le Beau M. M., Westbrook C. A., Diaz M. O., Larson R. A., Rowley J. D., Gasson J. C., Golde D. W., Sherr C. J. Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders. Science. 1986 Feb 28;231(4741):984–987. doi: 10.1126/science.3484837. [DOI] [PubMed] [Google Scholar]
  6. Mecucci C., Van den Berghe H., Michaux J. L., Bosly A., Doyen C. Paracentric inversions on the long arm of chromosome 5 in secondary myelodysplastic disorders. Cancer Genet Cytogenet. 1987 Nov;29(1):171–173. doi: 10.1016/0165-4608(87)90046-x. [DOI] [PubMed] [Google Scholar]
  7. Orazi A., Cattoretti G., Sozzi G., Miozzo M., Polli N., Delia D., Viviani S., Negretti E., Della Porta G., Rilke F. Morphologic, immunologic, and cytogenetic characteristics of secondary acute unclassifiable leukemia in Hodgkin's disease. Tumori. 1988 Aug 31;74(4):439–450. doi: 10.1177/030089168807400411. [DOI] [PubMed] [Google Scholar]
  8. Pedersen-Bjergaard J., Janssen W. G., Lyons J., Philip P., Bartram C. R. Point mutation of the ras protooncogenes and chromosome aberrations in acute nonlymphocytic leukemia and preleukemia related to therapy with alkylating agents. Cancer Res. 1988 Apr 1;48(7):1812–1817. [PubMed] [Google Scholar]
  9. Pedersen-Bjergaard J., Larsen S. O. Incidence of acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin's disease. N Engl J Med. 1982 Oct 14;307(16):965–971. doi: 10.1056/NEJM198210143071601. [DOI] [PubMed] [Google Scholar]
  10. Pedersen-Bjergaard J., Philip P. Cytogenetic characteristics of therapy-related acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive cases. Br J Haematol. 1987 Jun;66(2):199–207. doi: 10.1111/j.1365-2141.1987.tb01299.x. [DOI] [PubMed] [Google Scholar]
  11. Pedersen-Bjergaard J., Philip P., Pedersen N. T., Hou-Jensen K., Svejgaard A., Jensen G., Nissen N. I. Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. II. Bone marrow cytology, cytogenetics, results of HLA typing, response to antileukemic chemotherapy, and survival in a total series of 55 patients. Cancer. 1984 Aug 1;54(3):452–462. doi: 10.1002/1097-0142(19840801)54:3<452::aid-cncr2820540313>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  12. Rowley J. D., Golomb H. M., Vardiman J. W. Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease. Blood. 1981 Oct;58(4):759–767. [PubMed] [Google Scholar]
  13. Valagussa P., Santoro A., Kenda R., Fossati Bellani F., Franchi F., Banfi A., Rilke F., Bonadonna G. Second malignancies in Hodgkin's disease: a complication of certain forms of treatment. Br Med J. 1980 Jan 26;280(6209):216–219. doi: 10.1136/bmj.280.6209.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Yunis J. J. New chromosome techniques in the study of human neoplasia. Hum Pathol. 1981 Jun;12(6):540–549. doi: 10.1016/s0046-8177(81)80068-8. [DOI] [PubMed] [Google Scholar]
  15. Zarrabi M. H., Rosner F. Acute myeloblastic leukemia following treatment for non-hematopoietic cancers: report of 19 cases and review of the literature. Am J Hematol. 1979;7(4):357–367. doi: 10.1002/ajh.2830070408. [DOI] [PubMed] [Google Scholar]

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