Abstract
We have analysed 15 infiltrating duct carcinomas of the breast, 10 gastrointestinal adenocarcinomas, one each of the thyroid and larynx, and four mesenchymal tumours for the presence and the nature of procoagulant activity (PCA). The metastatic tumours had a significantly higher PCA (P = 0.01-0.001) as compared to the non-metastatic tumours in the respective groups, and almost 20-25 times the activity as compared to normal tissue (P = 0.001). Although the majority of the tumours had FVII-dependent tissue thromboplastin-like activity, some of the tumour homogenates revealed the presence of an FVII-independent PCA. Unlike the known alternate PCA, which acts via factor X activation, this PCA was factor X independent. It caused clot formation in FX-deficient plasma (six cases) and purified fibrinogen solution (four cases), indicating the presence of a Xa-like enzyme or a thrombin-like activity respectively.
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- Bick R. L. Alterations of hemostasis associated with malignancy: etiology, pathophysiology, diagnosis and management. Semin Thromb Hemost. 1978 Summer;5(1):1–26. doi: 10.1055/s-0028-1087142. [DOI] [PubMed] [Google Scholar]
- Cajot J. F., Kruithof E. K., Schleuning W. D., Sordat B., Bachmann F. Plasminogen activators, plasminogen activator inhibitors and procoagulant analyzed in twenty human tumor cell lines. Int J Cancer. 1986 Nov 15;38(5):719–727. doi: 10.1002/ijc.2910380516. [DOI] [PubMed] [Google Scholar]
- Curatolo L., Colucci M., Cambini A. L., Poggi A., Morasca L., Donati M. B., Semeraro N. Evidence that cells from experimental tumours can activate coagulation factor X. Br J Cancer. 1979 Aug;40(2):228–233. doi: 10.1038/bjc.1979.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gordon S. G., Cross B. A. A factor X-activating cysteine protease from malignant tissue. J Clin Invest. 1981 Jun;67(6):1665–1671. doi: 10.1172/JCI110203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hilgard P., Whur P. Factor X-activating activity from Lewis lung carcinoma. Br J Cancer. 1980 Apr;41(4):642–643. doi: 10.1038/bjc.1980.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Markus G. The role of hemostasis and fibrinolysis in the metastatic spread of cancer. Semin Thromb Hemost. 1984 Jan;10(1):61–70. doi: 10.1055/s-2007-1004408. [DOI] [PubMed] [Google Scholar]
- O'MEARA R. A. Coagulative properties of cancers. Ir J Med Sci. 1958 Oct;394:474–479. [PubMed] [Google Scholar]
- Rickles F. R., Edwards R. L. Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood. 1983 Jul;62(1):14–31. [PubMed] [Google Scholar]