Abstract
In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse here data on haemoglobin adducts of 14 aromatic amines in order to ascertain if the inter-individual variability left unexplained by tobacco smoking could be attributed to differences in individual metabolic patterns. For this purpose we computed residuals from analysis of variance in order to adjust for individual smoking habits (type and amount of tobacco). Residuals were correlated within two clearly distinct groups: one formed by binuclear compounds (4-aminobiphenyl, 3-aminobiphenyl and 2-naphthylamine) and the other formed by all other (i.e. mononuclear) compounds. Within each group, highly statistically significant correlation coefficients were found, whereas compounds belonging to one group were not correlated to compounds in the other group. These results can be interpreted as a suggestion that two different metabolic pathways exist, one for binuclear and one for mononuclear arylamines, and that inter-individual differences in such pathways can explain part of inter-individual variability in adduct levels. This interpretation is consistent with recent animal experiments suggesting that there are different enzyme systems for the two classes of compounds.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bryant M. S., Vineis P., Skipper P. L., Tannenbaum S. R. Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9788–9791. doi: 10.1073/pnas.85.24.9788. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guengerich F. P. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res. 1988 Jun 1;48(11):2946–2954. [PubMed] [Google Scholar]
- Nowak D., Schmidt-Preuss U., Jörres R., Liebke F., Rüdiger H. W. Formation of DNA adducts and water-soluble metabolites of benzo[a]pyrene in human monocytes is genetically controlled. Int J Cancer. 1988 Feb 15;41(2):169–173. doi: 10.1002/ijc.2910410202. [DOI] [PubMed] [Google Scholar]
- Schulte P. A. The role of genetic factors in bladder cancer. Cancer Detect Prev. 1988;11(3-6):379–388. [PubMed] [Google Scholar]
- Short C. R., Joseph M., Hardy M. L. Covalent binding of [14C]-2,6-dimethylaniline to DNA of rat liver and ethmoid turbinate. J Toxicol Environ Health. 1989;27(1):85–94. doi: 10.1080/15287398909531280. [DOI] [PubMed] [Google Scholar]
- Vineis P., Estève J., Terracini B. Bladder cancer and smoking in males: types of cigarettes, age at start, effect of stopping and interaction with occupation. Int J Cancer. 1984 Aug 15;34(2):165–170. doi: 10.1002/ijc.2910340205. [DOI] [PubMed] [Google Scholar]