Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1990 Feb;61(2):263–266. doi: 10.1038/bjc.1990.48

Cyclic AMP binding proteins and prognosis in breast cancer.

W R Miller 1, R A Elton 1, J M Dixon 1, U Chetty 1, D M Watson 1
PMCID: PMC1971390  PMID: 2155642

Abstract

Cyclic AMP binding proteins were measured in the primary tumour from 100 patients with non-disseminated breast cancer selected on the basis that sufficient tumour material was available for analysis. These measurements have been related to factors of established prognostic value and to the patients' disease-free interval and survival. There was a wide variation in amounts of binding proteins in different tumours. Values were significantly higher (P less than 0.05) in oestrogen receptor-negative tumours but no statistically significant correlations were apparent between levels and tumour grade or whether the patients had lymph node metastasis or adjuvant treatment. However, levels were significantly higher in patients whose disease recurred within 3 years of primary treatment as compared with those who remained disease-free. Using a retrospectively determined cut off point of 8 pmol mg-1 cytosol protein, it was shown that patients with tumour cyclic AMP binding in excess of this value had a significantly greater chance of developing recurrent disease and poorer survival rates (P less than 0.001 by Cox analysis) than those with lower levels. This remained true when other prognostic factors were taken into account in a multivariate analysis. It is suggested that the level of tumour cyclic AMP binding may be an independent prognostic factor for patients with early breast cancer.

Full text

PDF
263

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLOOM H. J., RICHARDSON W. W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957 Sep;11(3):359–377. doi: 10.1038/bjc.1957.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bodwin J. S., Clair T., Cho-Chung Y. S. Inverse relation between estrogen receptors and cyclic adenosine 3':5'-monophosphate-binding proteins in hormone-dependent mammary tumor regression due to dibutyryl cyclic adenosine 3':5'-monophosphate treatment or ovariectomy. Cancer Res. 1978 Oct;38(10):3410–3413. [PubMed] [Google Scholar]
  3. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 May 7;72:248–254. doi: 10.1016/0003-2697(76)90527-3. [DOI] [PubMed] [Google Scholar]
  4. Cho-Chung Y. S., Clair T., Schwimmer M., Steinberg L., Rego J., Grantham F. Cyclic adenosine 3':5-monophosphate receptor proteins in hormone-dependent and -independent rat mammary tumors. Cancer Res. 1981 May;41(5):1840–1846. [PubMed] [Google Scholar]
  5. Cho-Chung Y. S. On the mechanism of cyclic AMP-mediated growth arrest of solid tumors. Adv Cyclic Nucleotide Res. 1980;12:111–121. [PubMed] [Google Scholar]
  6. Hawkins R. A., Hill A., Freedman B. A simple method for the determination of oestrogen receptor concentrations in breast tumours and other tissues. Clin Chim Acta. 1975 Oct 15;64(2):203–210. doi: 10.1016/0009-8981(75)90202-8. [DOI] [PubMed] [Google Scholar]
  7. Kvinnsland S., Ekanger R., Døskeland S. O., Thorsen T. Relationship of cyclic AMP binding capacity and estrogen receptor to hormone sensitivity in human breast cancer. Breast Cancer Res Treat. 1983;3(1):67–72. doi: 10.1007/BF01806235. [DOI] [PubMed] [Google Scholar]
  8. Miller W. R., Senbanjo R. O., Telford J., Watson D. M. Cyclic AMP binding proteins in human breast cancer. Br J Cancer. 1985 Oct;52(4):531–535. doi: 10.1038/bjc.1985.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Miller W. R., Telford J., Dixon J. M., Hawkins R. A. Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity. Eur J Cancer Clin Oncol. 1985 Apr;21(4):539–542. doi: 10.1016/0277-5379(85)90049-5. [DOI] [PubMed] [Google Scholar]
  10. Senbanjo R. O., Miller W. R., Hawkins R. A. Variations in steroid receptors and cyclic AMP binding proteins across human breast cancers: evidence for heterogeneity. Br J Cancer. 1986 Jul;54(1):127–130. doi: 10.1038/bjc.1986.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Watson D. M., Hawkins R. A., Bundred N. J., Stewart H. J., Miller W. R. Tumour cyclic AMP binding proteins and endocrine responsiveness in patients with inoperable breast cancer. Br J Cancer. 1987 Aug;56(2):141–142. doi: 10.1038/bjc.1987.172. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES