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. 1990 Sep;62(3):364–367. doi: 10.1038/bjc.1990.298

The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.

S R Musk 1, G G Steel 1
PMCID: PMC1971459  PMID: 2169851

Abstract

A human bladder carcinoma cell line was irradiated at high and low dose rates and exposed to camptothecin and VP16, inhibitors of topoisomerase I and topoisomerase II respectively. Although camptothecin substantially modified the cytotoxic effects of high dose rate irradiation, abolished low dose rate sparing and inhibited the repair of sublethal and potentially lethal damage, VP16 had no effect on the survival curves even at highly cytotoxic doses. Thus, it is argued that there is a role for topoisomerase I but not topoisomerase II in the repair of DNA damage induced by ionising radiation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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