Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
editorial
. 1990 Nov;62(5):705–707. doi: 10.1038/bjc.1990.363

Morphine: pharmacokinetics and clinical practice.

P J Hoskin, G W Hanks
PMCID: PMC1971540  PMID: 2245160

Full text

PDF
705

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aitkenhead A. R., Vater M., Achola K., Cooper C. M., Smith G. Pharmacokinetics of single-dose i.v. morphine in normal volunteers and patients with end-stage renal failure. Br J Anaesth. 1984 Aug;56(8):813–819. doi: 10.1093/bja/56.8.813. [DOI] [PubMed] [Google Scholar]
  2. Al-Sayed-Omar O., Johnston A., Turner P. Influence of pH on the buccal absorption of morphine sulphate and its major metabolite, morphine-3-glucuronide. J Pharm Pharmacol. 1987 Nov;39(11):934–935. doi: 10.1111/j.2042-7158.1987.tb03132.x. [DOI] [PubMed] [Google Scholar]
  3. Berkowitz B. A. The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone. Clin Pharmacokinet. 1976;1(3):219–230. doi: 10.2165/00003088-197601030-00004. [DOI] [PubMed] [Google Scholar]
  4. Bodenham A., Quinn K., Park G. R. Extrahepatic morphine metabolism in man during the anhepatic phase of orthotopic liver transplantation. Br J Anaesth. 1989 Oct;63(4):380–384. doi: 10.1093/bja/63.4.380. [DOI] [PubMed] [Google Scholar]
  5. Dahlström B. E., Paalzow L. K. Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat. J Pharmacokinet Biopharm. 1978 Dec;6(6):505–519. doi: 10.1007/BF01062106. [DOI] [PubMed] [Google Scholar]
  6. Fisher A. P., Fung C., Hanna M. Serum morphine concentrations after buccal and intramuscular morphine administration. Br J Clin Pharmacol. 1987 Dec;24(6):685–687. doi: 10.1111/j.1365-2125.1987.tb03232.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Glare P. A., Walsh T. D., Pippenger C. E. Normorphine, a neurotoxic metabolite? Lancet. 1990 Mar 24;335(8691):725–726. doi: 10.1016/0140-6736(90)90840-2. [DOI] [PubMed] [Google Scholar]
  8. Hanks G. W., Hoskin P. J., Aherne G. W., Chapman D., Turner P., Poulain P. Enterohepatic circulation of morphine. Lancet. 1988 Feb 27;1(8583):469–469. doi: 10.1016/s0140-6736(88)91256-1. [DOI] [PubMed] [Google Scholar]
  9. Hanks G. W., Hoskin P. J., Aherne G. W., Turner P., Poulain P. Explanation for potency of repeated oral doses of morphine? Lancet. 1987 Sep 26;2(8561):723–725. doi: 10.1016/s0140-6736(87)91083-x. [DOI] [PubMed] [Google Scholar]
  10. Hanning C. D., Vickers A. P., Smith G., Graham N. B., McNeil M. E. The morphine hydrogel suppository. A new sustained release rectal preparation. Br J Anaesth. 1988 Aug;61(2):221–227. doi: 10.1093/bja/61.2.221. [DOI] [PubMed] [Google Scholar]
  11. Hoskin P. J., Hanks G. W., Aherne G. W., Chapman D., Littleton P., Filshie J. The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br J Clin Pharmacol. 1989 Apr;27(4):499–505. doi: 10.1111/j.1365-2125.1989.tb05399.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hoskin P. J., Hanks G. W., Heron C. W., Aherne G. W., Chapman D. M6G and its analgesic action in chronic use. Clin J Pain. 1989 Jun;5(2):199–200. [PubMed] [Google Scholar]
  13. Hoskin P. J., Hanks G. W. The management of symptoms in advanced cancer: experience in a hospital-based continuing care unit. J R Soc Med. 1988 Jun;81(6):341–344. doi: 10.1177/014107688808100615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kaiko R. F. Age and morphine analgesia in cancer patients with postoperative pain. Clin Pharmacol Ther. 1980 Dec;28(6):823–826. doi: 10.1038/clpt.1980.241. [DOI] [PubMed] [Google Scholar]
  15. LASAGNA L., DE KORNFELD T. J. Analgesic potency of normorphine in patients with postoperative pain. J Pharmacol Exp Ther. 1958 Nov;124(3):260–263. [PubMed] [Google Scholar]
  16. Leslie S. T., Rhodes A., Black F. M. Controlled release morphine sulphate tablets--a study in normal volunteers. Br J Clin Pharmacol. 1980 May;9(5):531–534. doi: 10.1111/j.1365-2125.1980.tb05858.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mazoit J. X., Sandouk P., Zetlaoui P., Scherrmann J. M. Pharmacokinetics of unchanged morphine in normal and cirrhotic subjects. Anesth Analg. 1987 Apr;66(4):293–298. [PubMed] [Google Scholar]
  18. Osborne R. J., Joel S. P., Slevin M. L. Morphine intoxication in renal failure: the role of morphine-6-glucuronide. Br Med J (Clin Res Ed) 1986 Jun 14;292(6535):1548–1549. doi: 10.1136/bmj.292.6535.1548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pasternak G. W., Bodnar R. J., Clark J. A., Inturrisi C. E. Morphine-6-glucuronide, a potent mu agonist. Life Sci. 1987 Dec 28;41(26):2845–2849. doi: 10.1016/0024-3205(87)90431-0. [DOI] [PubMed] [Google Scholar]
  20. Poulain P., Hoskin P. J., Hanks G. W., A-Omar O., Walker V. A., Johnston A., Turner P., Aherne G. W. Relative bioavailability of controlled release morphine tablets (MST continus) in cancer patients. Br J Anaesth. 1988 Nov;61(5):569–574. doi: 10.1093/bja/61.5.569. [DOI] [PubMed] [Google Scholar]
  21. Poulain P., Ribon A. M., Hanks G. W., Hoskin P. J., Aherne G. W., Chapman D. J. CSF concentrations of morphine-6-glucuronide after oral administration of morphine. Pain. 1990 Apr;41(1):115–116. doi: 10.1016/0304-3959(90)91116-Z. [DOI] [PubMed] [Google Scholar]
  22. Schäli C., Roch-Ramel F. Transport and metabolism of [3H]morphine in isolated, nonperfused proximal tubular segments of the rabbit kidney. J Pharmacol Exp Ther. 1982 Dec;223(3):811–815. [PubMed] [Google Scholar]
  23. Säwe J., Odar-Cederlöf I. Kinetics of morphine in patients with renal failure. Eur J Clin Pharmacol. 1987;32(4):377–382. doi: 10.1007/BF00543973. [DOI] [PubMed] [Google Scholar]
  24. Woolner D. F., Winter D., Frendin T. J., Begg E. J., Lynn K. L., Wright G. J. Renal failure does not impair the metabolism of morphine. Br J Clin Pharmacol. 1986 Jul;22(1):55–59. doi: 10.1111/j.1365-2125.1986.tb02880.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES