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. 1991 Jan;63(1):67–70. doi: 10.1038/bjc.1991.14

Co-stimulation of gastrointestinal tumour cell growth by gastrin, transforming growth factor alpha and insulin like growth factor-I.

L G Durrant 1, S A Watson 1, A Hall 1, D L Morris 1
PMCID: PMC1971664  PMID: 1846553

Abstract

Epidermal growth factor receptors and insulin like growth factor-I receptors were co-expressed on two gastric and three colorectal tumour cell lines. Previous studies have shown that gastrin receptors were also expressed at a low level or two of these cell lines. Both TGF alpha and IGF-I promoted cell growth in all of the cell lines tested. The cell doubling time of a colorectal cell line was reduced from 48 to 30-34 h. Furthermore the effects of the growth factors were additive. Each growth factor also increased the response of the cells to gastrin, but a combination of both growth factors and gastrin did not further increase growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin G. S., Knesel J., Monckton J. M. Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase. Nature. 1983 Feb 3;301(5899):435–437. doi: 10.1038/301435a0. [DOI] [PubMed] [Google Scholar]
  2. Bennett C., Paterson I. M., Corbishley C. M., Luqmani Y. A. Expression of growth factor and epidermal growth factor receptor encoded transcripts in human gastric tissues. Cancer Res. 1989 Apr 15;49(8):2104–2111. [PubMed] [Google Scholar]
  3. Coffey R. J., Jr, Goustin A. S., Soderquist A. M., Shipley G. D., Wolfshohl J., Carpenter G., Moses H. L. Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. Cancer Res. 1987 Sep 1;47(17):4590–4594. [PubMed] [Google Scholar]
  4. Coffey R. J., Jr, Shipley G. D., Moses H. L. Production of transforming growth factors by human colon cancer lines. Cancer Res. 1986 Mar;46(3):1164–1169. [PubMed] [Google Scholar]
  5. Cormier E. M., Wolf M. F., Jordan V. C. Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth. Cancer Res. 1989 Feb 1;49(3):576–580. [PubMed] [Google Scholar]
  6. Culouscou J. M., Remacle-Bonnet M., Garrouste F., Marvaldi J., Pommier G. Simultaneous production of IGF-I and EGF competing growth factors by HT-29 human colon cancer line. Int J Cancer. 1987 Nov 15;40(5):646–652. doi: 10.1002/ijc.2910400513. [DOI] [PubMed] [Google Scholar]
  7. Derynck R., Goeddel D. V., Ullrich A., Gutterman J. U., Williams R. D., Bringman T. S., Berger W. H. Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Res. 1987 Feb 1;47(3):707–712. [PubMed] [Google Scholar]
  8. Dickson R. B., Lippman M. E. Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr Rev. 1987 Feb;8(1):29–43. doi: 10.1210/edrv-8-1-29. [DOI] [PubMed] [Google Scholar]
  9. Durrant L. G., Ballantyne K. C., Armitage N. C., Robins R. A., Marksman R., Hardcastle J. D., Baldwin R. W. Quantitation of MHC antigen expression on colorectal tumours and its association with tumour progression. Br J Cancer. 1987 Oct;56(4):425–432. doi: 10.1038/bjc.1987.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hoosein N. M., Brattain D. E., McKnight M. K., Levine A. E., Brattain M. G. Characterization of the inhibitory effects of transforming growth factor-beta on a human colon carcinoma cell line. Cancer Res. 1987 Jun 1;47(11):2950–2954. [PubMed] [Google Scholar]
  11. Morris D. L., Watson S. A., Durrant L. G., Harrison J. D. Hormonal control of gastric and colorectal cancer in man. Gut. 1989 Apr;30(4):425–429. doi: 10.1136/gut.30.4.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tahara E., Sumiyoshi H., Hata J., Yasui W., Taniyama K., Hayashi T., Nagae S., Sakamoto S. Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy. Jpn J Cancer Res. 1986 Feb;77(2):145–152. [PubMed] [Google Scholar]
  13. Townsend C. M., Jr, Beauchamp R. D., Singh P., Thompson J. C. Growth factors and intestinal neoplasms. Am J Surg. 1988 Mar;155(3):526–536. doi: 10.1016/s0002-9610(88)80128-4. [DOI] [PubMed] [Google Scholar]
  14. Tricoli J. V., Rall L. B., Karakousis C. P., Herrera L., Petrelli N. J., Bell G. I., Shows T. B. Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res. 1986 Dec;46(12 Pt 1):6169–6173. [PubMed] [Google Scholar]
  15. Wakeling A. E., Newboult E., Peters S. W. Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells. J Mol Endocrinol. 1989 May;2(3):225–234. doi: 10.1677/jme.0.0020225. [DOI] [PubMed] [Google Scholar]
  16. Watson S. A., Durrant L. G., Crosbie J. D., Morris D. L. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer. 1989 Apr 15;43(4):692–696. doi: 10.1002/ijc.2910430425. [DOI] [PubMed] [Google Scholar]
  17. Watson S. A., Durrant L. G., Morris D. L. Growth-promoting action of gastrin on human colonic and gastric tumour cells cultured in vitro. Br J Surg. 1988 Apr;75(4):342–345. doi: 10.1002/bjs.1800750416. [DOI] [PubMed] [Google Scholar]
  18. Watson S., Durrant L., Morris D. Gastrin: growth enhancing effects on human gastric and colonic tumour cells. Br J Cancer. 1989 Apr;59(4):554–558. doi: 10.1038/bjc.1989.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yasui W., Hata J., Yokozaki H., Nakatani H., Ochiai A., Ito H., Tahara E. Interaction between epidermal growth factor and its receptor in progression of human gastric carcinoma. Int J Cancer. 1988 Feb 15;41(2):211–217. doi: 10.1002/ijc.2910410209. [DOI] [PubMed] [Google Scholar]

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