Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1990 Jun;61(6):809–812. doi: 10.1038/bjc.1990.182

Studies of the L-myc DNA polymorphism and relation to metastasis in Norwegian lung cancer patients.

T Tefre 1, A L Børresen 1, S Aamdal 1, A Brøgger 1
PMCID: PMC1971690  PMID: 1973618

Abstract

We studied 83 lung cancer patients and 129 controls for the EcoRI polymorphism of the L-myc gene. No association was found between the L-myc RFLP and increased risk of metastasis, either to lymph nodes or metastasis to other organs. There was no difference in survival time between the three different genotypes. The S-allele of the L-myc RFLP has been correlated to increased metastasis in lung cancer. We found no tendency towards a higher frequency of this allele in the cohort of patients with positive family history compared to the patients with no known first degree relatives with cancer. A higher frequency of the S-allele in the adenocarcinomas compared to other histological groups was found, although this difference was not statistically significant. No difference in the gene frequency of the L-myc RFLP was found between the lung cancer patients and the normal controls. These results are in contrast with a previous report. Possible explanations for the discrepancies are discussed.

Full text

PDF
809

Images in this article

810Figure 1
on p.810

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alt F. W., DePinho R., Zimmerman K., Legouy E., Hatton K., Ferrier P., Tesfaye A., Yancopoulos G., Nisen P. The human myc gene family. Cold Spring Harb Symp Quant Biol. 1986;51(Pt 2):931–941. doi: 10.1101/sqb.1986.051.01.106. [DOI] [PubMed] [Google Scholar]
  2. Anton-Culver H., Culver B. D., Kurosaki T., Osann K. E., Lee J. B. Incidence of lung cancer by histological type from a population-based registry. Cancer Res. 1988 Nov 15;48(22):6580–6583. [PubMed] [Google Scholar]
  3. Bishop J. M. The molecular genetics of cancer. Science. 1987 Jan 16;235(4786):305–311. doi: 10.1126/science.3541204. [DOI] [PubMed] [Google Scholar]
  4. De Greve J., Battey J., Fedorko J., Birrer M., Evan G., Kaye F., Sausville E., Minna J. The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs. Mol Cell Biol. 1988 Oct;8(10):4381–4388. doi: 10.1128/mcb.8.10.4381-4388.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983 Jul 1;132(1):6–13. doi: 10.1016/0003-2697(83)90418-9. [DOI] [PubMed] [Google Scholar]
  6. Heighway J., Thatcher N., Cerny T., Hasleton P. S. Genetic predisposition to human lung cancer. Br J Cancer. 1986 Apr;53(4):453–457. doi: 10.1038/bjc.1986.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ikeda I., Ishizaka Y., Ochiai M., Sakai R., Itabashi M., Onda M., Sugimura T., Nagao M. No correlation between L-myc restriction fragment length polymorphism and malignancy of human colorectal cancers. Jpn J Cancer Res. 1988 Jun;79(6):674–676. doi: 10.1111/j.1349-7006.1988.tb02220.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kakehi Y., Yoshida O. Restriction fragment length polymorphism of the L-myc gene and susceptibility to metastasis in renal cancer patients. Int J Cancer. 1989 Mar 15;43(3):391–394. doi: 10.1002/ijc.2910430307. [DOI] [PubMed] [Google Scholar]
  9. Kawashima K., Shikama H., Imoto K., Izawa M., Naruke T., Okabayashi K., Nishimura S. Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2353–2356. doi: 10.1073/pnas.85.7.2353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kaye F., Battey J., Nau M., Brooks B., Seifter E., De Greve J., Birrer M., Sausville E., Minna J. Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. Mol Cell Biol. 1988 Jan;8(1):186–195. doi: 10.1128/mcb.8.1.186-195.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Krystal G., Birrer M., Way J., Nau M., Sausville E., Thompson C., Minna J., Battey J. Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer. Mol Cell Biol. 1988 Aug;8(8):3373–3381. doi: 10.1128/mcb.8.8.3373-3381.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kvåle G., Johansen A. Lungekreft i Norge. En oversikt basert på Kreftregisterets materiale. Tidsskr Nor Laegeforen. 1982 Mar 20;102(8):480–484. [PubMed] [Google Scholar]
  13. Saksela K. Expression of the L-myc gene is under positive control by short-lived proteins. Oncogene. 1987;1(3):291–296. [PubMed] [Google Scholar]
  14. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  15. Zimmerman K. A., Yancopoulos G. D., Collum R. G., Smith R. K., Kohl N. E., Denis K. A., Nau M. M., Witte O. N., Toran-Allerand D., Gee C. E. Differential expression of myc family genes during murine development. 1986 Feb 27-Mar 5Nature. 319(6056):780–783. doi: 10.1038/319780a0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES