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. 1990 Jul;62(1):61–64. doi: 10.1038/bjc.1990.229

Protection of rat spermatogenic epithelium from damage induced by procarbazine chemotherapy.

L M Glode 1, J M Shannon 1, N Malik 1, T Nett 1
PMCID: PMC1971720  PMID: 2117966

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ataya K. M., McKanna J. A., Weintraub A. M., Clark M. R., LeMaire W. J. A luteinizing hormone-releasing hormone agonist for the prevention of chemotherapy-induced ovarian follicular loss in rats. Cancer Res. 1985 Aug;45(8):3651–3656. [PubMed] [Google Scholar]
  2. Berndtson W. E., Pickett B. W., Nett T. M. Reproductive physiology of the stallion. IV. Seasonal changes in the testosterone concentration of peripheral plasma. J Reprod Fertil. 1974 Jul;39(1):115–118. doi: 10.1530/jrf.0.0390115. [DOI] [PubMed] [Google Scholar]
  3. Chapman R. M., Sutcliffe S. B., Malpas J. S. Cytotoxic-induced ovarian failure in Hodgkin's disease. II. Effects on sexual function. JAMA. 1979 Oct 26;242(17):1882–1884. [PubMed] [Google Scholar]
  4. Delic J. I., Bush C., Peckham M. J. Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen. Cancer Res. 1986 Apr;46(4 Pt 2):1909–1914. [PubMed] [Google Scholar]
  5. Delic J. I., Harwood J. R., Stanley J. A. Time dependence for the protective effect of androgen from procarbazine-induced damage to rat spermatogenesis. Cancer Res. 1987 Mar 1;47(5):1344–1347. [PubMed] [Google Scholar]
  6. Glode L. M., Robinson J., Gould S. F. Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotropin-releasing hormone. Lancet. 1981 May 23;1(8230):1132–1134. doi: 10.1016/s0140-6736(81)92301-1. [DOI] [PubMed] [Google Scholar]
  7. Goodpasture J. C., Bergstrom K., Vickery B. H. Potentiation of the gonadotoxicity of Cytoxan in the dog by adjuvant treatment with a luteinizing hormone-releasing hormone agonist. Cancer Res. 1988 Apr 15;48(8):2174–2178. [PubMed] [Google Scholar]
  8. Gould S. F., Powell D., Nett T., Glode L. M. A rat model for chemotherapy-induced male infertility. Arch Androl. 1983 Oct;11(2):141–150. doi: 10.3109/01485018308987473. [DOI] [PubMed] [Google Scholar]
  9. Johnson D. H., Linde R., Hainsworth J. D., Vale W., Rivier J., Stein R., Flexner J., Van Welch R., Greco F. A. Effect of a luteinizing hormone releasing hormone agonist given during combination chemotherapy on posttherapy fertility in male patients with lymphoma: preliminary observations. Blood. 1985 Apr;65(4):832–836. [PubMed] [Google Scholar]
  10. Karashima T., Zalatnai A., Schally A. V. Protective effects of analogs of luteinizing hormone-releasing hormone against chemotherapy-induced testicular damage in rats. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2329–2333. doi: 10.1073/pnas.85.7.2329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. King D. J., Ratcliffe M. A., Dawson A. A., Bennett B., Macgregor J. E., Klopper A. I. Fertility in young men and women after treatment for lymphoma: a study of a population. J Clin Pathol. 1985 Nov;38(11):1247–1251. doi: 10.1136/jcp.38.11.1247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lefebvre F. A., Bélanger A., Pelletier G., Labrie F. Recovery of gonadal functions in the adult male rat following cessation of five-month daily treatment with an LHRH agonist. J Androl. 1984 May-Jun;5(3):181–192. doi: 10.1002/j.1939-4640.1984.tb02391.x. [DOI] [PubMed] [Google Scholar]
  13. Lewis R. W., Dowling K. J., Schally A. V. D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons. Proc Natl Acad Sci U S A. 1985 May;82(9):2975–2979. doi: 10.1073/pnas.82.9.2975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Niswender G. D., Midgley A. R., Jr, Monroe S. E., Reichert L. E., Jr Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131-I. Proc Soc Exp Biol Med. 1968 Jul;128(3):807–811. doi: 10.3181/00379727-128-33129. [DOI] [PubMed] [Google Scholar]
  15. Pogach L. M., Lee Y., Gould S., Giglio W., Huang H. F. Partial prevention of procarbazine induced germinal cell aplasia in rats by sequential GnRH antagonist and testosterone administration. Cancer Res. 1988 Aug 1;48(15):4354–4360. [PubMed] [Google Scholar]
  16. Rivier C., Rivier J., Vale W. Chronic effects of [D-Trp6,Pro9-NEt]luteinizing hormone-releasing factor on reproductive processes in the male rat. Endocrinology. 1979 Nov;105(5):1191–1201. doi: 10.1210/endo-105-5-1191. [DOI] [PubMed] [Google Scholar]
  17. Rivkees S. A., Crawford J. D. The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA. 1988 Apr 8;259(14):2123–2125. [PubMed] [Google Scholar]
  18. Schilsky R. L., Lewis B. J., Sherins R. J., Young R. C. Gonadal dysfunction in patients receiving chemotherapy for cancer. Ann Intern Med. 1980 Jul;93(1):109–114. doi: 10.7326/0003-4819-93-1-109. [DOI] [PubMed] [Google Scholar]
  19. Schilsky R. L., Sherins R. J., Hubbard S. M., Wesley M. N., Young R. C., DeVita V. T. Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease. Am J Med. 1981 Oct;71(4):552–556. doi: 10.1016/0002-9343(81)90205-9. [DOI] [PubMed] [Google Scholar]
  20. Sherins R. J., DeVita V. T., Jr Effect of drug treatment for lymphoma on male reproductive capacity. Studies of men in remission after therapy. Ann Intern Med. 1973 Aug;79(2):216–220. doi: 10.7326/0003-4819-79-2-216. [DOI] [PubMed] [Google Scholar]
  21. Sherins R. J., Olweny C. L., Ziegler J. L. Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin's disease. N Engl J Med. 1978 Jul 6;299(1):12–16. doi: 10.1056/NEJM197807062990103. [DOI] [PubMed] [Google Scholar]
  22. Stratton L. G., Ewing L. L., Desjardins C. Efficacy of testosterone-filled polydimethylsiloxane implants in maintaining plasma testosterone in rabbits. J Reprod Fertil. 1973 Nov;35(2):235–244. doi: 10.1530/jrf.0.0350235. [DOI] [PubMed] [Google Scholar]
  23. Viviani S., Santoro A., Ragni G., Bonfante V., Bestetti O., Bonadonna G. Gonadal toxicity after combination chemotherapy for Hodgkin's disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol. 1985 May;21(5):601–605. doi: 10.1016/0277-5379(85)90088-4. [DOI] [PubMed] [Google Scholar]
  24. Waxman J. Cancer, chemotherapy, and fertility. Br Med J (Clin Res Ed) 1985 Apr 13;290(6475):1096–1097. doi: 10.1136/bmj.290.6475.1096. [DOI] [PMC free article] [PubMed] [Google Scholar]

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