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. 1990 Aug;62(2):296–298. doi: 10.1038/bjc.1990.281

Magnetic resonance imaging in the detection of skeletal metastases in patients with breast cancer.

A L Jones 1, M P Williams 1, T J Powles 1, J F Oliff 1, J R Hardy 1, G Cherryman 1, J Husband 1
PMCID: PMC1971828  PMID: 2386746

Abstract

Eighty-four patients with breast cancer at high risk of bone metastases were investigated with magnetic resonance imaging (MRI) of the thoracolumbar spine. Of 58 patients with normal limited skeletal surveys (LSS) and bone scans (BS), 4 (7%) had MR images compatible with malignant infiltration. Fourteen patients had abnormal bone scans with normal or non-diagnostic plain films; 7 of these patients (50%) had MR images compatible with malignant infiltration. Twelve patients had single or multiple wedge collapses of uncertain aetiology on plain film; MR demonstrated metastatic disease as the cause of wedge collapse in 7 (58%). MRI may define a group of patients with extra-osseous relapse who have occult metastatic disease. Although the detection rate in patients with primary breast cancer is low (4/45), MRI is of value in determining the cause of wedge collapse in postmenopausal women with breast cancer and may elucidate the cause of an abnormal bone scan with normal or non-diagnostic plain films.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Daffner R. H., Lupetin A. R., Dash N., Deeb Z. L., Sefczek R. J., Schapiro R. L. MRI in the detection of malignant infiltration of bone marrow. AJR Am J Roentgenol. 1986 Feb;146(2):353–358. doi: 10.2214/ajr.146.2.353. [DOI] [PubMed] [Google Scholar]
  2. Edelstyn G. A., Gillespie P. J., Grebbell F. S. The radiological demonstration of osseous metastases. Experimental observations. Clin Radiol. 1967 Apr;18(2):158–162. doi: 10.1016/s0009-9260(67)80010-2. [DOI] [PubMed] [Google Scholar]
  3. FRIEDELL G. H., BETTS A., SOMMERS S. C. THE PROGNOSTIC VALUE OF BLOOD VESSEL INVASION AND LYMPHOCYTIC INFILTRATES IN BREAST CARCINOMA. Cancer. 1965 Feb;18:164–166. doi: 10.1002/1097-0142(196502)18:2<164::aid-cncr2820180207>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  4. Fisher B., Slack N. H., Bross I. D. Cancer of the breast: size of neoplasm and prognosis. Cancer. 1969 Nov;24(5):1071–1080. doi: 10.1002/1097-0142(196911)24:5<1071::aid-cncr2820240533>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  5. Fisher B., Slack N. H. Number of lymph nodes examined and the prognosis of breast carcinoma. Surg Gynecol Obstet. 1970 Jul;131(1):79–88. [PubMed] [Google Scholar]
  6. Galasko C. S., Doyle F. H. The detection of skeletal metastases from mammary cancer. A regional comparison between radiology and scintigraphy. Clin Radiol. 1972 Jul;23(3):295–297. doi: 10.1016/s0009-9260(72)80051-5. [DOI] [PubMed] [Google Scholar]
  7. Godersky J. C., Smoker W. R., Knutzon R. Use of magnetic resonance imaging in the evaluation of metastatic spinal disease. Neurosurgery. 1987 Nov;21(5):676–680. doi: 10.1227/00006123-198711000-00013. [DOI] [PubMed] [Google Scholar]
  8. Hajek P. C., Baker L. L., Goobar J. E., Sartoris D. J., Hesselink J. R., Haghighi P., Resnick D. Focal fat deposition in axial bone marrow: MR characteristics. Radiology. 1987 Jan;162(1 Pt 1):245–249. doi: 10.1148/radiology.162.1.3786770. [DOI] [PubMed] [Google Scholar]
  9. Kamby C., Guldhammer B., Vejborg I., Rossing N., Dirksen H., Daugaard S., Mouridsen H. T. The presence of tumor cells in bone marrow at the time of first recurrence of breast cancer. Cancer. 1987 Sep 15;60(6):1306–1312. doi: 10.1002/1097-0142(19870915)60:6<1306::aid-cncr2820600624>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  10. Mansi J. L., Berger U., Easton D., McDonnell T., Redding W. H., Gazet J. C., McKinna A., Powles T. J., Coombes R. C. Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases. Br Med J (Clin Res Ed) 1987 Oct 31;295(6606):1093–1096. doi: 10.1136/bmj.295.6606.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Muindi J., Coombes R. C., Golding S., Powles T. J., Khan O., Husband J. The role of computed tomography in the detection of bone metastases in breast cancer patients. Br J Radiol. 1983 Apr;56(664):233–236. doi: 10.1259/0007-1285-56-664-233. [DOI] [PubMed] [Google Scholar]
  12. Redding W. H., Coombes R. C., Monaghan P., Clink H. M., Imrie S. F., Dearnaley D. P., Ormerod M. G., Sloane J. P., Gazet J. C., Powles T. J. Detection of micrometastases in patients with primary breast cancer. Lancet. 1983 Dec 3;2(8362):1271–1274. doi: 10.1016/s0140-6736(83)91150-9. [DOI] [PubMed] [Google Scholar]
  13. Smoker W. R., Godersky J. C., Knutzon R. K., Keyes W. D., Norman D., Bergman W. The role of MR imaging in evaluating metastatic spinal disease. AJR Am J Roentgenol. 1987 Dec;149(6):1241–1248. doi: 10.2214/ajr.149.6.1241. [DOI] [PubMed] [Google Scholar]
  14. Vogler J. B., 3rd, Murphy W. A. Bone marrow imaging. Radiology. 1988 Sep;168(3):679–693. doi: 10.1148/radiology.168.3.3043546. [DOI] [PubMed] [Google Scholar]
  15. Williams M. P., Cherryman G. R., Husband J. E. Magnetic resonance imaging in suspected metastatic spinal cord compression. Clin Radiol. 1989 May;40(3):286–290. doi: 10.1016/s0009-9260(89)80205-3. [DOI] [PubMed] [Google Scholar]

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