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. 1990 Aug;62(2):263–266. doi: 10.1038/bjc.1990.273

Analysis by DNA polymerase alpha activity of human breast tumour proliferation and the effect of endocrine therapy.

N G Coldham 1, L C Lai 1, M J Reed 1, M W Ghilchik 1, N A Shaikh 1, V H James 1
PMCID: PMC1971841  PMID: 2143678

Abstract

Cytosols of human breast tumours have been assayed for DNA dependent DNA polymerase alpha activity. DNA polymerase alpha activity in benign tumours was found to be significantly lower than in untreated malignant tumours. Biopsy samples removed surgically before and after endocrine therapy showed reduced DNA polymerase alpha activity in 6 out of 9 patients treated with 4-hydroxyandrostenedione, and in 6 out of 7 patients treated with MPA. DNA polymerase alpha activity in malignant breast tumours was higher in oestrogen receptor negative than oestrogen receptor positive tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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