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. 1991 Mar;63(3):447–450. doi: 10.1038/bjc.1991.103

The long term prognostic significance of c-erbB-2 in primary breast cancer.

J Winstanley 1, T Cooke 1, G D Murray 1, A Platt-Higgins 1, W D George 1, S Holt 1, M Myskov 1, A Spedding 1, B R Barraclough 1, P S Rudland 1
PMCID: PMC1971845  PMID: 1672256

Abstract

The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

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Selected References

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